【発明の名称】三環式誘導体、それらを含有する薬学的組成物

Japanese Patent JP2793915

B2

Disclosed are compounds of Formula I: (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: R3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl; R4 is H, alkyl, alkenyl, alkoxy, or -OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor- alpha and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.

TEIN HOORIN SHII
SOROMON DANIERU ERU
FURIARII RICHAADO JEI
BIRAANI FURANKU JEI
PIUINSUKII JON JEI
RII JOO EFU
SEIRU BERA EI
JAKUEI JEEMUZU PII
BASHI DEIRU BII

JP51622395A

September 03, 1998

December 05, 1994

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SHEERINGU PURAU CORP

A61K31/125; A61K31/135; A61K31/18; A61K31/195; A61K31/335; A61K31/40; A61K31/4025; A61K31/403; A61K31/4035; A61K31/404; A61K31/44; A61K31/443; A61P29/00; A61P31/04; A61P35/00; A61P37/08; A61P43/00; C07C33/38; C07C45/44; C07C47/235; C07D295/02; C07C47/453; C07C69/608; C07C69/618; C07C211/26; C07C211/32; C07C215/42; C07C217/52; C07C229/14; C07C233/05; C07C233/18; C07C233/73; C07C251/40; C07C271/10; C07C271/12; C07C271/16; C07C311/03; C07C311/04; C07C311/17; C07D207/16; C07D209/08; C07D209/44; C07D209/48; C07D213/89; C07D221/16; C07D261/02; C07D295/03; C07D295/084; C07D313/12; C07D405/06; (IPC1-7): C07C217/52; A61K31/135; A61K31/195; A61K31/335; A61K31/40; C07C229/14; C07C233/05; C07C233/73; C07C251/40; C07C271/12; C07C311/03; C07D261/02; C07D313/12

JP4225953A

Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，１９７２，１５（６），６６５−６７３
Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ，１９７２，１５（７），７５０−７５４

Shusaku Yamamoto

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