Title:
【発明の名称】二本鎖オリゴヌクレオチド及びこれを有効成分とする制癌剤
Document Type and Number:
Japanese Patent JP3392143
Kind Code:
B2
Abstract:
This invention provides a double-stranded oligonucleotide or a derivative thereof which comprises 15 to 40 base pairs, wherein at least one side of the strands contains at least one nucleotide sequence represented by 5'-TTTSSCGS-3' (S is G or C). Also, since the compound of the present invention can inhibit expression of growth-related genes which are regulated by E2F, through its function to undergo sequence-specific competitive inhibition of the binding of E2F protein to the transcription region at a low concentration, a pharmaceutical composition containing the inventive compound as its active ingredient is useful as a drug having low side effects for use in the prevention and treatment of cancers.
Inventors:
Kenichi Matsuo
Hoichi Sugimoto
Kenji Suzuki
Keisuke Ishida
Yuji Yamada
Hoichi Sugimoto
Kenji Suzuki
Keisuke Ishida
Yuji Yamada
Application Number:
JP51672996A
Publication Date:
March 31, 2003
Filing Date:
November 16, 1995
Export Citation:
Assignee:
Taiho Pharmaceutical Co., Ltd.
International Classes:
C12N15/113; A61K38/00; (IPC1-7): C12N15/09; A61K31/70; A61P35/00
Other References:
Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓｅａｒｃｈ，Ｖｏｌ．１４，Ｎｏ．１３（１９８６），ｐ．５３８９−５３９８
Attorney, Agent or Firm:
Taira Hagino (5 outside)