Title:
【発明の名称】B細胞上のCD28レセプターに対するリガンドおよび該リガンドを用いた細胞間相互作用の調節方法
Document Type and Number:
Japanese Patent JPH06508501
Kind Code:
A
Abstract:
The invention identifies the B7 antigen as a ligand that is reactive with the CD28 receptor on T cells. Fragments and derivatives of the B7 antigen and CD28 receptor, including fusion proteins having amino acid sequences corresponding to the extracellular domains of B7 or CD28 joined to amino acid sequences encoding portions of human immunoglobulin C gamma 1, are described. Methods are provided for using B7 antigen, its fragments and derivatives, and the CD28 receptor, its fragments and derivatives, as well as antibodies and other molecules reactive with B7 antigen and/or the CD28 receptor, to regulate CD28 positive T cell responses, and immune responses mediated by T cells. The invention also includes an assay method for detecting ligands reactive with cellular receptors mediating intercellular adhesion.
Inventors:
Linsley Peter S
Red Better Jeffrey A
Damuru Nighting Kay
Bloody william
Red Better Jeffrey A
Damuru Nighting Kay
Bloody william
Application Number:
JP51362591A
Publication Date:
September 29, 1994
Filing Date:
July 01, 1991
Export Citation:
Assignee:
Bristol-Myers Squibb Company
International Classes:
A61K38/00; A61K39/00; A61K39/395; A61P37/00; C07K14/00; C07K14/705; C07K16/00; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/09; C12P21/02; C12P21/08; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/569; G01N33/577; C12R1/91; (IPC1-7): C12P21/02; A61K37/02; A61K39/00; A61K39/395; C07K15/12; C12P21/08; G01N33/53
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)