Title:
【発明の名称】レトロウイルス性粒子及びα-ガラクトシルエピトープの欠損した細胞系の調製方法
Document Type and Number:
Japanese Patent JPH10503647
Kind Code:
A
Abstract:
Methods and compositions are provided for facilitating gene therapy procedures involving the transduction of target cells with retroviral vector particles in the presence of complement containing body fluids. The reduction of levels of galactose alpha (1,3) galactosyl epitopes on the retroviral vector particles and/or the blockade of antibody binding to such epitopes have been found to render the particles less sensitive to inactivation by complement mediated mechanisms, and to thus allow transduction in the presence of complement containing body fluids. Means are provided for obtaining such reductions.
Inventors:
Rosser, russel pee
Rawlins, Scott A
Fodo, William Elle
Spring Horn, Jeremy Pee
Rawlins, Scott A
Fodo, William Elle
Spring Horn, Jeremy Pee
Application Number:
JP50579995A
Publication Date:
April 07, 1998
Filing Date:
July 14, 1995
Export Citation:
Assignee:
Aleksion Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K35/76; C07K16/10; C07K16/18; C12N5/10; C12N15/867; (IPC1-7): C12N15/09; A61K35/76; C12N5/10
Attorney, Agent or Firm:
Yuzo Yamazaki (1 person outside)