Title:
【発明の名称】光老化の作用を回復させるための皮膚の治療方法
Document Type and Number:
Japanese Patent JPH04500824
Kind Code:
A
Abstract:
The effects of photoaging or sun damage of skin including loss of collagen fibers and deterioration of small blood vessels in the dermis of the skin are repaired by applying topically to the epidermis effective amounts of a compound having structure (I), wherein R1, R2, R3, R4 and R5 are independently selected from the group consisting of H, Cl, OR6, straight or branched alkyl of 1 to 10 carbon atoms, NO2, COOR6, CN, OR6, NR6R7, NR6C(=S)NR7R8, NR6COR7, SO2NR6R7, CH(CH3)COOH, CONR6R7, COR6, OCONR6R7, NR6COONR7, R9OR6, NR6SO2R7, Si(CH3)3, and NR6CONR7R8, R3 together with R4 forms a benzo ring or taken together with R2 forms a benzo or tetrahydrobenzo ring or together with R2 and R1 forms a (1) moiety or together with R2 forms a (2) moiety or R2 together with R1 forms a benzo ring or R2 together with R3 forms a (3) or (4) or (5) or (6) moiety, or R1 is independently selected from the group consisting of (7), (8) moiety, R6, R7 and R8 are independently selected from the group consisting of straight or branched alkyl containing from 1 to 10 carbon atoms, aryl containing from 6 to 10 carbon atoms and hydrogen, and R9 is alkylene of 1 to 6 carbon atoms, and iron carbonyl complexes thereof, to an area of the skin in an amount sufficient to repair the effects of elastosis in the skin. Lines and wrinkles due to aging are reduced and prevented.
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Inventors:
Harry, nail fredric
Nea, Zaina
Jendime Menico, Gerald Joseph
Zushi, F. Christopher
Swan, Earl. Thomas
Nea, Zaina
Jendime Menico, Gerald Joseph
Zushi, F. Christopher
Swan, Earl. Thomas
Application Number:
JP51106790A
Publication Date:
February 13, 1992
Filing Date:
July 19, 1990
Export Citation:
Assignee:
Eastman Kodak Company
International Classes:
A61K31/215; A61K8/00; A61K8/49; A61K8/67; A61K31/23; A61K31/235; A61K31/27; A61K31/275; A61K31/365; A61K31/425; A61K31/44; A61K31/695; A61P17/00; A61Q19/00; A61Q19/08; C07D277/66; C07D455/04; (IPC1-7): A61K7/00; A61K31/215; A61K31/27; A61K31/275; A61K31/365; A61K31/695; C07D277/66; C07D455/04
Attorney, Agent or Firm:
Aoki Akira (3 outside)