MANUFACTURE OF 2-BROM-ALPHA-ERGORYPTINE OR METHYLATE OF SAME

Title:

MANUFACTURE OF 2-BROM-ALPHA-ERGORYPTINE OR METHYLATE OF SAME

Document Type and Number:

Japanese Patent JPS5849388

Kind Code:

A

Abstract:

alpha -Ergocryptine is reacted with 1,3-dibromo-5,5-dimethyl-2,4-imidazolinedione in an inert solvent at a temperature of 0 to 55 DEG C in the presence of 2,2'-azobisisobutyronitrile. The mixture obtained is concentrated under vacuum to dryness and the residue is dissolved in a low molecular weight halogenated solvent and washed with an aqueous inorganic base solution and with water. After drying, treatment with active charcoal and concentrating to a small volume, the product is separated from the mixture by column chromatography by eluting with the same halogenated solvent, ethanol being added until a concentration of 5% by volume is achieved. The product-rich fractions are concentrated to dryness and recrystallised. The product obtained may be converted to its mesylate by acidification with methanesulphonic acid in an inert solvent and then evaporated to crystallisation. The final products are used to inhibit prolactin secretion and to inhibit growth hormone.

Inventors:

RAFUAERU FUOGE
MARIAANO SORIANO
ANDOREASU BARUDEI

Application Number:

JP12781182A

Publication Date:

March 23, 1983

Filing Date:

July 23, 1982

Export Citation:

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