To provide a disease model associated with the inheritable predisposition of glaucoma, a method for screening a preventing or treating agent of the glaucoma by using the model and a material usable for the screening.

A non-human transgenic animal is provided by expressing a variant material of a WDR36 polypeptide deleted with one or several amino acid residues including the amino acid residue corresponding to aspartic acid at the 658th in a human WDR36 polypeptide, or its derivative in the WDR36 polypeptide of a mammalian animal.