Title:
プロトンポンプ阻害剤の経粘膜送達
Document Type and Number:
Japanese Patent JP2005521662
Kind Code:
A
Abstract:
The present invention relates to pharmaceutical compositions and methods for transmucosal delivery of proton pump inhibitors. In one embodiment, the pharmaceutical composition of the present invention comprises a core which comprises an antacid, and an outer layer surrounding the core. The outer layer contains a therapeutically effective amount of a proton pump inhibitor. In another embodiment, the pharmaceutical composition of the present invention comprises an outer layer which comprising a unidirectional film, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor. In yet another embodiment, the pharmaceutical composition of the present invention is a unidirectional tablet for delivery of a proton pump inhibitor across the oral mucosa. In this embodiment, the pharmaceutical composition contains an outer layer which contains a pharmaceutically acceptable water impermeable layer, and an inner layer which contains a therapeutically effective amount of a proton pump inhibitor.
Inventors:
Widder Ken
Hall warren
Olmsted Kai
Hall warren
Olmsted Kai
Application Number:
JP2003563534A
Publication Date:
July 21, 2005
Filing Date:
January 27, 2003
Export Citation:
Assignee:
Santalas Incorporated
International Classes:
A61K9/00; A61K9/24; A61K9/28; A61K9/42; A61K9/54; A61K9/70; A61K31/4439; A61K33/10; A61K45/06; A61K47/02; A61K47/14; A61K47/30; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/40; A61K47/42; A61K47/44; C07D401/12; A61P1/04; A61P43/00; (IPC1-7): A61K47/02; A61K9/28; A61K9/42; A61K9/54; A61K9/70; A61K31/4439; A61K47/14; A61K47/30; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/40; A61K47/42; A61K47/44; A61P1/04; A61P43/00
Domestic Patent References:
| JPH11501950A | 1999-02-16 | |||
| JP2001509791A | 2001-07-24 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi