Title:
TREATMENT OF NEGATIVE AND COGNITIVE SYMPTOM OF SCHIZOPHRENIA WITH GLYCINE UPTAKE ANTAGONIST
Document Type and Number:
Japanese Patent JP2009167205
Kind Code:
A
Abstract:
To provide a treatment method useful for psychosis such as major depression, manic depressive psychosis, Alzheimer's disease or post-traumatic stress syndrome, associated with drug intoxication caused by dissociative anesthetics and psychostimulants.
A glycine uptake antagonist in an amount sufficient to potentiate NMDA (N-methyl-D-aspartate) receptor-mediated neurotransmission and further, neuroleptic agent which is an antipsychotic medicine are administered to patients suffering from symptoms of psychosis and of schizophrenia in order to treat these symptoms.
Inventors:
JAVITT DANIEL C
Application Number:
JP2009066534A
Publication Date:
July 30, 2009
Filing Date:
March 18, 2009
Export Citation:
Assignee:
JAVITT DANIEL C
International Classes:
A61K45/00; A61K31/00; A61K31/16; A61K31/195; A61K31/198; A61K31/22; A61K31/223; A61K45/06; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P39/02; A61P43/00
Domestic Patent References:
| JPH0283317A | 1990-03-23 |
Foreign References:
| WO1993010228A1 | 1993-05-27 |
Other References:
JPN7011002210; Ｅｕｇｅｎｅ Ｔｏｔｈ， ｅｔ ａｌ．: Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎｓ ｉｎ Ｐｓｙｃｈｏｌｏｇｙ， Ｐｓｙｃｈｉａｔｒｙ ａｎｄ Ｂｅｈａｖｉｏｒ １１（１）, 1986, ｐｐ．１-９
JPN6011031655; Ｄａｎｉｅｌ Ｃ． Ｊａｖｉｔｔ， ｅｔ ａｌ．: Ａｍ． Ｊ． Ｐｓｙｃｈｉａｔｒｙ １４８, 1991, ｐｐ．１３０１-１３０８
JPN6011031656; ＴＯＳＨＩＴＡＫＡ ＮＡＢＥＳＨＩＭＡ， ｅｔ ａｌ．: Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ９１, 1983, ｐｐ．４５５-４６２
JPN6011031657; Ｌ． Ｊ． Ｂｒｉｓｔｏｗ， ｅｔ ａｌ．: Ｂｒ． Ｊ． Ｐｈａｒｍａｃｏｌ． １０８, 1993, ｐｐ．１１５６-１１６３
JPN6011031659; ＲＡＵＬ ＡＬＬＡＮ ＫＩＩＶＥＴ， ｅｔ ａｌ．: Ｂｒ． Ｊ． Ｃｌｉｎ． Ｐｈａｒｍａｃｏｌ． ４０, 1995, ｐｐ．４６７-４７６
JPN6011031660; 松野敏行ら: 九州神経精神医学 ４０（１）, 1994, ｐｐ．１１７-１２８
JPN6011031661; Ｆｒａｎｃｉｓｃｏ Ｚａｆｒａ， ｅｔ ａｌ．: Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ １５（５）, 1995, ｐｐ．３９５２-３９６９
JPN6011031655; Ｄａｎｉｅｌ Ｃ． Ｊａｖｉｔｔ， ｅｔ ａｌ．: Ａｍ． Ｊ． Ｐｓｙｃｈｉａｔｒｙ １４８, 1991, ｐｐ．１３０１-１３０８
JPN6011031656; ＴＯＳＨＩＴＡＫＡ ＮＡＢＥＳＨＩＭＡ， ｅｔ ａｌ．: Ｅｕｒｏｐｅａｎ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ ９１, 1983, ｐｐ．４５５-４６２
JPN6011031657; Ｌ． Ｊ． Ｂｒｉｓｔｏｗ， ｅｔ ａｌ．: Ｂｒ． Ｊ． Ｐｈａｒｍａｃｏｌ． １０８, 1993, ｐｐ．１１５６-１１６３
JPN6011031659; ＲＡＵＬ ＡＬＬＡＮ ＫＩＩＶＥＴ， ｅｔ ａｌ．: Ｂｒ． Ｊ． Ｃｌｉｎ． Ｐｈａｒｍａｃｏｌ． ４０, 1995, ｐｐ．４６７-４７６
JPN6011031660; 松野敏行ら: 九州神経精神医学 ４０（１）, 1994, ｐｐ．１１７-１２８
JPN6011031661; Ｆｒａｎｃｉｓｃｏ Ｚａｆｒａ， ｅｔ ａｌ．: Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｓｃｉｅｎｃｅ １５（５）, 1995, ｐｐ．３９５２-３９６９
Attorney, Agent or Firm:
Seiji Ohno
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Samejima Mutsumi
Kyousei Tamura
Kitahara Yasuhiro
Koji Morita
Reiko Tanaka
Yuko Matsuniya
Ken Kitano
Natsuki Ito
Samejima Mutsumi
Kyousei Tamura
Kitahara Yasuhiro
Previous Patent: IMPROVED 3DS HOME CARE AGENT
Next Patent: IN VITRO PRODUCTION OF DENDRITIC CELL FROM CD 14+ MONOCYTE
Next Patent: IN VITRO PRODUCTION OF DENDRITIC CELL FROM CD 14+ MONOCYTE