Title:
腫瘍画像化化合物
Document Type and Number:
Japanese Patent JP4611017
Kind Code:
B2
Abstract:
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) analogs namely, their rapid uptake and prolonged retention in tumors with the properties of halogen substituents, including certain useful halogen isotopes such as fluorine-18, iodine-123, iodine-124, iodine-125, iodine-131, bromine-75, bromine-76, bromine-77, bromine-82, astatine-210, astatine-211, and other astatine isotopes. In addition the compounds can be labeled with technetium and rhenium isotopes using known chelation complexes. The amino acid compounds disclosed herein have a high specificity for target sites when administered to a subject in vivo. The labeled amino acid compounds are useful as imaging agents in detecting and/or monitoring tumors in a subject by Positron Emission Tomography (PET) and Single Photon Emission Computer Tomography (SPECT).
Inventors:
Goodman, Mark M.
McConasy, Jonathan
McConasy, Jonathan
Application Number:
JP2004501548A
Publication Date:
January 12, 2011
Filing Date:
April 24, 2003
Export Citation:
Assignee:
Emory University
International Classes:
C07C229/20; G01T1/161; A61K51/00; A61K51/04; C07C229/22; C07F13/00
Domestic Patent References:
| JP2000500442A |
Other References:
C.G.Wermuth 編、長瀬 博 監訳,最新 創薬化学 上巻,1998年 8月15日,353-388頁
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita