Title:
単一特異性ポリペプチド試薬
Document Type and Number:
Japanese Patent JP2013511966
Kind Code:
A
Abstract:
The present invention relates to a novel antigen-binding protein construct or “modubody”, which contains at least three functional single domain modules of an antibody. The modubodies contain a domain from the heavy chain variable region of an antibody (VH), a domain from the light chain variable region of an antibody (VL) and bind monospecifically to an antigen. The modubodies further contain a domain from the constant region of antibodies. The modubodies can be used for diagnostic or therapeutic purposes.
Inventors:
Robert Poppe
Application Number:
JP2012540419A
Publication Date:
April 11, 2013
Filing Date:
November 24, 2010
Export Citation:
Assignee:
Orgentech Diagnostica Gaem Behr
International Classes:
C12N15/09; A61K35/12; A61K39/395; A61K48/00; A61P43/00; C07K16/00; C07K16/46; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; G01N33/531
Domestic Patent References:
| JP2007528194A | 2007-10-11 | |||
| JP2003501096A | 2003-01-14 | |||
| JP2000516452A | 2000-12-12 | |||
| JP2009544300A | 2009-12-17 |
Foreign References:
| WO2008131242A1 | 2008-10-30 | |||
| WO2005017148A1 | 2005-02-24 |
Other References:
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OLAFSEN, T. ET AL., PROTEIN ENG. DES. SEL., vol. 17, no. 4, JPN6014053649, 2004, pages 315 - 323, ISSN: 0002968154
ARNDT, K.M. ET AL., BIOCHEMISTRY, vol. 37, JPN6015039471, 1998, pages 12918 - 12926, ISSN: 0003166010
TURNER, D.J. ET AL., J. IMMUNOL. METHODS, vol. 205, JPN6015039473, 1997, pages 43 - 54, ISSN: 0003166011
DESPLANCQ, D. ET AL., PROTEIN ENG., vol. 7, no. 8, JPN6016017600, 1994, pages 1027 - 1033, ISSN: 0003315607
FAST, J.L. ET AL., BIOCHEMISTRY, vol. 48, JPN6016017605, 11 September 2009 (2009-09-11), pages 11724 - 11736, ISSN: 0003315608
HU, S. ET AL., CANCER RES., vol. 56, JPN6016017603, 1996, pages 3055 - 3061, ISSN: 0003315609
JUNG, S. AND PLUCKTHUN, A., PROTEIN ENG., vol. 10, no. 8, JPN6016017607, 1997, pages 959 - 966, ISSN: 0003315610
ANDERSEN, C.B. ET AL., PROTEIN SCI., vol. 19, JPN6016017609, 15 December 2009 (2009-12-15), pages 279 - 290, ISSN: 0003315611
LI, E. ET AL., PROTEIN ENG., vol. 10, no. 6, JPN6014053644, 1997, pages 731 - 736, ISSN: 0002968151
SHAO, C. AND ZHANG, J., CELL. MOL. IMMUNOL., vol. 5, no. 4, JPN6014053645, 2008, pages 299 - 306, ISSN: 0002968152
WU, A.M. ET AL., PROTEIN ENG., vol. 14, no. 12, JPN6014053647, 2001, pages 1025 - 1033, ISSN: 0002968153
OLAFSEN, T. ET AL., PROTEIN ENG. DES. SEL., vol. 17, no. 4, JPN6014053649, 2004, pages 315 - 323, ISSN: 0002968154
Attorney, Agent or Firm:
Yasuhiko Murayama
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro
Masatake Shiga
Takashi Watanabe
Shinya Mitsuhiro