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Title:
USE OF ESSENTIAL OIL FOR ENHANCING BIOAVAILABILITY OF ORAL PHARMACEUTICAL COMPOUND
Document Type and Number:
Japanese Patent JP2009046498
Kind Code:
A
Abstract:

To identify a composition exhibiting excellent performances for enhancing drug bioavailability, particularly enhancing drug bioavailability by enhancing net drug absorption and/or reducing drug biotransformation in the intestinal wall by inhibiting cytochrome P450 drug metabolism and/or inhibiting P-glycoprotein (P-gp) drug transport.

One or more kinds of essential oils are concurrently administered with one or more kinds of oral pharmaceutical compounds (drugs) thereby to enhance bioavailability of the drug.


Inventors:
BENET LESLIE Z
WACHER VINCENT J
BENET REED M
Application Number:
JP2008255329A
Publication Date:
March 05, 2009
Filing Date:
September 30, 2008
Export Citation:
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Assignee:
EASTMAN CHEM CO
International Classes:
A61K47/44; A61K9/00; A61K31/337; A61K36/13; A61K36/14; A61K36/15; A61K36/185; A61K36/23; A61K36/235; A61K36/25; A61K36/28; A61K36/282; A61K36/324; A61K36/328; A61K36/45; A61K36/48; A61K36/53; A61K36/532; A61K36/534; A61K36/537; A61K36/54; A61K36/57; A61K36/61; A61K36/63; A61K36/67; A61K36/738; A61K36/80; A61K36/8962; A61K36/898; A61K36/899; A61K36/9064; A61K36/9068; A61K38/00; A61K38/13; A61K47/10; A61K47/48; A61P43/00
Domestic Patent References:
JPH04356420A1992-12-10
JPS6466122A1989-03-13
JPS62270523A1987-11-24
JPS6415A1989-01-05
JPS5770815A1982-05-01
JPS5877810A1983-05-11
Foreign References:
WO1990008537A11990-08-09
WO1983003548A11983-10-27
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura