Title:
免疫応答を上昇させるための熱ショックタンパク質の使用
Document Type and Number:
Japanese Patent JP2005529124
Kind Code:
A
Abstract:
The present invention provides for a method of using heat shock proteins (HSPs) to amplify the immune response initiated by a vaccine. HSPs can be introduced into a subject before, concurrently, or after the administration of a vaccine. The HSPs can also be used to activate antigen presenting cells which are then introduced into a subject in conjunction with a vaccine. The HSPs used in the methods of the invention can be unbound or can be covalently or noncovalently bound to a peptide that is unrelated to the vaccine. The subject is preferably mammalian, and most preferably human. It is shown by way of example herein that HSPs induces secretion of cytokines and surface expression of antigen-presenting and co-stimulatory molecules. The invention also encompasses methods of treatment and prevention of cancer and infectious diseases in a subject.
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Inventors:
Srivastava, Pramod, Kay.
Application Number:
JP2003587326A
Publication Date:
September 29, 2005
Filing Date:
April 25, 2003
Export Citation:
Assignee:
University of Connecticut Health Center
International Classes:
A61K45/00; A61K38/17; A61K39/00; A61K39/005; A61K39/008; A61K39/012; A61K39/02; A61K39/04; A61K39/095; A61K39/118; A61K39/12; A61K39/13; A61K39/145; A61K39/165; A61K39/20; A61K39/21; A61K39/235; A61K39/245; A61K39/25; A61K39/29; A61K39/39; A61P31/04; A61P35/00; A61P35/02; A61P43/00; C07K14/47; (IPC1-7): A61K39/00; A61K39/005; A61K39/008; A61K39/012; A61K39/04; A61K39/095; A61K39/118; A61K39/12; A61K39/13; A61K39/145; A61K39/165; A61K39/20; A61K39/21; A61K39/235; A61K39/245; A61K39/25; A61K39/29; A61K39/39; A61K45/00; A61P31/04; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita