Title:
USE OF MIXED MICELL
Document Type and Number:
Japanese Patent JPH04244021
Kind Code:
A
Abstract:
PURPOSE: To enable orally safe treatment, especially to newborn babies by using vitamin K1 in the form of an aqueous solution of mixed micelle comprising a cholanoic acid salt and phospholipid. CONSTITUTION: Vitamin K1 is used in the form of an aqueous solution of mixed micelle in production of oral vitamin K1 formulation in order to orally administer vitamin K1 to newborn babies. A cholanoic acid salt (especially glycocholic acid) and phospholipid (especially lecithin) are used as the mixed micelle. For example, glycocolic acid is dissolved in purified water Ph. Eur by using sodium hydroxide and pH of the solution is adjusted to 5.5 by using hydrochloric acid. Lecithin is dissolved in sodium glycocholate solution while stirring and vitamin K1 is added thereto while stirring. Purified water Ph.Eur. is added to the resultant vitamin K1 mixed micelle solution and pH of the solution is adjusted to 6.0 by using hydrochloric acid and purified water Ph. Eur. is added to the solution and the solution is filtered to provide a vitamin K1 mixed micelle solution.
Inventors:
ORIBAA AMEDEEMANESUMU
YOZEFU GURIYUTAA
ARUFURETSUDO HANKU
YOZEFU GURIYUTAA
ARUFURETSUDO HANKU
Application Number:
JP22633591A
Publication Date:
September 01, 1992
Filing Date:
August 13, 1991
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K9/107; A61K31/12; A61K31/122; A61K47/28; A61P3/02; (IPC1-7): A61K9/107; A61K31/12; A61K47/28
Attorney, Agent or Firm:
Heiyoshi Odashima
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