Title:
バリアントアクチビン受容体ポリペプチドおよびその使用
Document Type and Number:
Japanese Patent JP5496682
Kind Code:
B2
Abstract:
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Inventors:
Jeong Hoon
Tom, Ray-Tin Tony
Han, Fuku
Quak, Keith Soo-Nyun
Butterfly, xiaolan
Tom, Ray-Tin Tony
Han, Fuku
Quak, Keith Soo-Nyun
Butterfly, xiaolan
Application Number:
JP2009552758A
Publication Date:
May 21, 2014
Filing Date:
March 06, 2008
Export Citation:
Assignee:
Amgen Incorporated
International Classes:
C12N15/09; A61K35/76; A61K38/00; A61K48/00; A61P3/00; A61P3/04; A61P3/10; A61P9/10; A61P11/00; A61P13/00; A61P13/12; A61P17/02; A61P19/00; A61P19/02; A61P21/00; A61P31/18; A61P35/00; A61P43/00; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP2006516886A |
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Reiko Izumiya