Title:
β-アミロイドアナログ-T細胞エピトープワクチン
Document Type and Number:
Japanese Patent JP2004538332
Kind Code:
A
Abstract:
Disclosed are novel methods for combatting diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protien (APP) or beta amyloid (A²). Immunization is preferably effected by administration of analogues of autologous APP or A², said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous A² which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Also disclosed are nucleic acid vaccination against APP or A² and vaccination using live vaccines as well as methods and means useful for the vaccination. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
Inventors:
Rasmussen, Petter, Beak
Jensen, martin, roland
Nielsen, Claus, Gregory
Coefoed, Petter
Degan, Florence, Dull
Jensen, martin, roland
Nielsen, Claus, Gregory
Coefoed, Petter
Degan, Florence, Dull
Application Number:
JP2003520770A
Publication Date:
December 24, 2004
Filing Date:
August 20, 2002
Export Citation:
Assignee:
Farmex A/S
International Classes:
C12N15/09; A61K35/74; A61K35/76; A61K38/00; A61K39/00; A61K39/02; A61K39/10; A61K39/12; A61K39/385; A61K39/39; A61K39/395; A61K45/06; A61K48/00; A61P3/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; A61K; A61P; C07K; (IPC1-7): A61K38/00; A61K35/74; A61K35/76; A61K39/00; A61K39/02; A61K39/12; A61K39/39; A61K39/395; A61K48/00; A61P3/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
| JP2003523402A | 2003-08-05 |
Foreign References:
| WO2000072880A2 | 2000-12-07 | |||
| WO2001042306A2 | 2001-06-14 | |||
| WO1999027944A1 | 1999-06-10 | |||
| WO2000020027A2 | 2000-04-13 | |||
| WO1999058564A1 | 1999-11-18 |
Attorney, Agent or Firm:
Shintaro Nogawa