Title:
The anthra pyridazone derivative asymmetrically replaced as a cell-growth depressant
Document Type and Number:
Japanese Patent JP6013451
Kind Code:
B2
Abstract:
The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).
Inventors:
Borrowski, edward
Stephaniska, Barbara
Dujidishka, Maria
Siblerski, Martin
Sherezewski, Vislow
Of Cowitz, Yanuche
Bontemps-Graz, Maria
Wizocca, Margol Zata
Maserski, Jan
Punda, Powell
Vitelik, Joanna
Stephaniska, Barbara
Dujidishka, Maria
Siblerski, Martin
Sherezewski, Vislow
Of Cowitz, Yanuche
Bontemps-Graz, Maria
Wizocca, Margol Zata
Maserski, Jan
Punda, Powell
Vitelik, Joanna
Application Number:
JP2014505102A
Publication Date:
October 26, 2016
Filing Date:
April 13, 2012
Export Citation:
Assignee:
BS-154 SP. ZO.O.
International Classes:
C07D237/26; A61K31/502; A61K31/5025; A61K45/00; A61P35/00; C07D487/04
Other References:
STEFANSKA BARBARA,SYNTHESIS AND BIOLOGICAL EVALUATION OF 2,7-DIHYDRO-3H-DIBENZO[DE,H]CINNOLINE-3, 7-DIONE DERIVATIVES, A NOVEL GROUP OF ANTICANCER AGENTS ACTIVE ON A MULTIDRUG RESISTANT CELL LINE,BIOORGANIC & MEDICINAL CHEMISTRY,2003年,V11,P561-572
DZIEDUSZYCKA M,SYNTHESIS OF NEW POLYCYCLIC ANTHRACENEDIONE ANALOGS WITH HETERO- OR CARBOCYCLIC RING(S) FUSED TO THE CHROMOPHORE SYSTEM,POLISH J. CHEM.,2007年,V81,P535-545,FUSED TO THE CHROMOPHORE SYSTEM
BOROWSKI EDWARD,STRATEGIES FOR OVERCOMING ABC-TRANSPORTERS-MEDIATED MULTIDRUG RESISTANCE (MDR) OF TUMOR CELLS,ACTA BIOCHIMICA POLONICA,2005年,V52 N3,P609-627
Jolanta Pawlowska et al.,Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.,Oncology Research,2003年,Vol.13,PP.245-252
DOKUNIKHIN N S,PYRIDAZONEATHRONE AND ITS DERIVATIVES I,ZHURNAL OBSHCHEI KHIMII,1964年,V34 N7
DZIEDUSZYCKA M,SYNTHESIS OF NEW POLYCYCLIC ANTHRACENEDIONE ANALOGS WITH HETERO- OR CARBOCYCLIC RING(S) FUSED TO THE CHROMOPHORE SYSTEM,POLISH J. CHEM.,2007年,V81,P535-545,FUSED TO THE CHROMOPHORE SYSTEM
BOROWSKI EDWARD,STRATEGIES FOR OVERCOMING ABC-TRANSPORTERS-MEDIATED MULTIDRUG RESISTANCE (MDR) OF TUMOR CELLS,ACTA BIOCHIMICA POLONICA,2005年,V52 N3,P609-627
Jolanta Pawlowska et al.,Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase.,Oncology Research,2003年,Vol.13,PP.245-252
DOKUNIKHIN N S,PYRIDAZONEATHRONE AND ITS DERIVATIVES I,ZHURNAL OBSHCHEI KHIMII,1964年,V34 N7
Attorney, Agent or Firm:
Ippei Watanabe
Koji Kikawa
Hiroyuki Sato
Shigeru Koike
Koji Kikawa
Hiroyuki Sato
Shigeru Koike
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