A cell strain of the lymphocyte containing gammadelta T-lymph cell, its constituent, and a manufacturing method for the same

Title:

A cell strain of the lymphocyte containing gammadelta T-lymph cell, its constituent, and a manufacturing method for the same

Document Type and Number:

Japanese Patent JP6086904

Kind Code:

B2

Abstract:

The present invention shows that human Vδ1+ NCR+ T cells can be differentiated and expanded from total γδ peripheral blood lymphocytes (PBLs), upon regular in vitro or ex vivo stimulation with γδTCR agonists and γc-family cytokines. This subset surprisingly expresses NKp30, NKp44 and NKp46, and high levels of Granzyme B that associate with highly enhanced cytotoxicity against lymphoid leukemias.

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Inventors:

De Carvalho y Silva Santos, Bruno Miguel
Vargas Correira, Daniel

Application Number:

JP2014510941A

Publication Date:

March 01, 2017

Filing Date:

May 21, 2012

Export Citation:

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Assignee:

Institute de Medicina Molecular

International Classes:

C12N5/0783; A61K35/14; A61P1/14; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P31/14; A61P31/22; A61P35/00; A61P35/02; A61P37/02; C12N5/07; C12N5/078

Other References:

AIDS,2008年,Vol.22,p.217-226
J. Exp. Med.,2010年,Vol.207, No.4,p.807-821
JAIDS,2003年,Vol.33, No.4,p.420-425
Infection,2009年,Vol.37, Suppl. II,p.81-82,PO 075

Attorney, Agent or Firm:

Creation International Patent Office

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