Title:
抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
Document Type and Number:
Japanese Patent JP6403668
Kind Code:
B2
Abstract:
Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for treating an inflammatory disease which includes an antibody that specifically recognizes a myosin regulatory light chain polypeptide (hereinafter abbreviated asMyl), preferably Myl9, Myl12a, and Myl12b,and inhibits a result of an effect of coexistence of Myl with CD69; a method of treating an inflammatory disease, including administering, to a subject diagnosed as having an inflammatory disease, a therapeutically effective amount of the antibody; and a method of identifying a compound that inhibits a result of an effect of coexistence of Myl with CD69, and a method of identifying a candidate compound for treating an inflammatory disease, including selecting a compound that inhibits the result.
Inventors:
Toshinori Nakayama
Hiroyuki Hosokawa
Koji Tsuneda
Hiroshi Hayashizaki
Suzuki Akane
Hiroyuki Hosokawa
Koji Tsuneda
Hiroshi Hayashizaki
Suzuki Akane
Application Number:
JP2015519959A
Publication Date:
October 10, 2018
Filing Date:
May 30, 2014
Export Citation:
Assignee:
National University Corporation Chiba University
International Classes:
A61K39/395; A61P11/00; A61P29/00; A61P37/08; G01N33/15; G01N33/50; G01N33/566
Domestic Patent References:
| JP2009508812A |
Foreign References:
| WO2008105058A1 |
Other References:
脳21,2000年,3(4),p.453-456
Nat. Immunol.,2008年,9(8),p.880-886
Nat. Immunol.,2008年,9(8),p.880-886
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga