Title:
A compound and a constituent
Document Type and Number:
Japanese Patent JP6068457
Kind Code:
B2
Abstract:
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
Inventors:
Garvey, David, Es.
Application Number:
JP2014515939A
Publication Date:
January 25, 2017
Filing Date:
June 13, 2012
Export Citation:
Assignee:
Become Pharmaceuticals, Inc.
International Classes:
C07C25/18; A61K31/03; A61K31/045; A61K31/12; A61K31/277; A61K31/341; A61K31/381; A61P27/02; A61P27/10; A61P43/00; C07C31/13; C07C33/34; C07C33/50; C07C43/23; C07C49/553; C07C49/567; C07C49/577; C07C255/53; C07C255/56; C07D307/42; C07D307/46; C07D333/16; C07D333/22
Domestic Patent References:
| JP1153617A | ||||
| JP2011502983A | ||||
| JP2001348353A | ||||
| JP8073335A | ||||
| JP50117961A | ||||
| JP2002114738A |
Foreign References:
| WO2010147653A1 | ||||
| CN101504399A | ||||
| US4292447 | ||||
| US3180892 |
Other References:
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CHEMISCHE BERICHTE,1992年,VOL.125,NO.10,PP.2319-2324
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TETRAHEDRON,1980年,VOL.36,NO.12,PP.1885-1889
JOURNAL OF ORGANIC CHEMISTRY,2008年,VOL.73,NO.13,PP.4962-4970
HELVETICA CHIMICA ACTA,1963年,VOL.46,NO.2,PP.483-492
CHEMISCHE BERICHTE,1992年,VOL.125,NO.10,PP.2319-2324
TETRAHEDRON LETTERS,1985年,VOL.26,NO.35,PP.4175-4178
HELVETICA CHIMICA ACTA,1973年,VOL.56,NO.7,PP.2548-2563
TETRAHEDRON,1980年,VOL.36,NO.12,PP.1885-1889
JOURNAL OF ORGANIC CHEMISTRY,2008年,VOL.73,NO.13,PP.4962-4970
HELVETICA CHIMICA ACTA,1963年,VOL.46,NO.2,PP.483-492
Attorney, Agent or Firm:
Hiroyuki Niwa
Eiko Nakamura
Nishio Mira
Eiko Nakamura
Nishio Mira