Title:
The constituent for endothelin 1 production control, and the constituent for cell-growth promotion
Document Type and Number:
Japanese Patent JP6058532
Kind Code:
B2
Abstract:
Provided is a composition for inhibiting endoserine-1 production, a skin-whitening composition, a composition for promoting cell proliferation, and a composition for improvement of wrinkles and sagging, which comprise as the active ingredient thereof a compound represented by general formula (1) or general formula (5).
Inventors:
Yuya Hayashi
Application Number:
JP2013512433A
Publication Date:
January 11, 2017
Filing Date:
April 26, 2012
Export Citation:
Assignee:
Rohto Pharmaceutical Co., Ltd.
International Classes:
A61K8/60; A61K31/7048; A61P17/16; A61P43/00; A61Q19/00; A61Q19/02; A61Q19/08
Domestic Patent References:
| JP2005343803A | 2005-12-15 | |||
| JP2009209063A | 2009-09-17 | |||
| JP2003514839A | 2003-04-22 |
Foreign References:
| WO2010030000A1 | 2010-03-18 | |||
| US20050271608A1 | 2005-12-08 | |||
| US20060074108A1 | 2006-04-06 |
Other References:
JPN6012037812; 沢辺昭義 他: '美に挑む！植物性化粧品原料' Ｆｏｏｄｓ ＆ Ｆｏｏｄ Ｉｎｇｒｅｄｉｅｎｔｓ Ｊ． Ｊｐｎ． Ｖｏｌ．２１３， Ｎｏ．１０, 2008, ｐ．８９７-９０９
JPN6012037813; 正木仁: 'チロシナーゼ活性測定法および美白効果評価法' ＦＲＡＧＲＡＮＣＥ ＪＯＵＲＮＡＬ 臨時増刊，Ｎｏ．１８, 2003, ｐ．３５-４１
JPN6012037814; 八谷輝: 'エンドセリンとＳＣＦからみたシミの生成メカニズム研究' ＦＲＡＧＲＡＮＣＥ ＪＯＵＲＮＡＬ 臨時増刊，Ｎｏ．１８, 2003, ｐ．９-１５
JPN6012037815; ＬＩ， Ｙ． ｅｔ ａｌ．: 'Ｉｍｐｒｏｖｅｍｅｎｔ ｉｎ ｔｈｅ Ｔｕｒｎｏｖｅｒ Ｒａｔｅ ｏｆ ｔｈｅ Ｓｔｒａｔｕｍ Ｃｏｒｎｅｕｍ ｉｎ Ｆａｌｓｅ Ａｇｅｄ Ｍｏｄｅｌ Ｒａｔｓ ｂｙ ｔｈｅ Ａｄｍｉｎｉｓｔｒａｔｉ' Ｂｉｏｌ． Ｐｈａｒｍ． Ｂｕｌｌ． Ｖｏｌ．２２， Ｎｏ．６, 1999, ｐ．５８２-５８５
JPN6012037816; ＨＯＵＧＨＴＯＮ， Ｐ． Ｊ． ｅｔ ａｌ．: 'Ｂｕｄｄｌｅｊａ ａｎｄ Ｗｏｕｎｄ Ｈｅａｌｉｎｇ' ＳＯＦＷ-Ｊｏｕｒｎａｌ Ｖｏｌ．１２３， Ｎｏ．１, 1997, ｐ．４０-４３
JPN6012037817; ＨＯ， Ｊ． Ｎ．: 'Ｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔｓ ｏｆ Ａｕｃｕｂｉｎ Ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｅｕｃｏｍｍｉａ ｕｌｍｏｉｄｅｓ ａｇａｉｎｓｔ ＵＶＢ-Ｉｎｄｕｃｅｄ Ｏｘｉｄａｔｉｖｅ Ｓｔｒｅｓｓ ｉ' Ｂｉｏｌ． Ｐｈａｒｍ． Ｂｕｌｌ． Ｖｏｌ．２８， Ｎｏ．７, 2005, ｐ．１２４４-１２４８
JPN6012037813; 正木仁: 'チロシナーゼ活性測定法および美白効果評価法' ＦＲＡＧＲＡＮＣＥ ＪＯＵＲＮＡＬ 臨時増刊，Ｎｏ．１８, 2003, ｐ．３５-４１
JPN6012037814; 八谷輝: 'エンドセリンとＳＣＦからみたシミの生成メカニズム研究' ＦＲＡＧＲＡＮＣＥ ＪＯＵＲＮＡＬ 臨時増刊，Ｎｏ．１８, 2003, ｐ．９-１５
JPN6012037815; ＬＩ， Ｙ． ｅｔ ａｌ．: 'Ｉｍｐｒｏｖｅｍｅｎｔ ｉｎ ｔｈｅ Ｔｕｒｎｏｖｅｒ Ｒａｔｅ ｏｆ ｔｈｅ Ｓｔｒａｔｕｍ Ｃｏｒｎｅｕｍ ｉｎ Ｆａｌｓｅ Ａｇｅｄ Ｍｏｄｅｌ Ｒａｔｓ ｂｙ ｔｈｅ Ａｄｍｉｎｉｓｔｒａｔｉ' Ｂｉｏｌ． Ｐｈａｒｍ． Ｂｕｌｌ． Ｖｏｌ．２２， Ｎｏ．６, 1999, ｐ．５８２-５８５
JPN6012037816; ＨＯＵＧＨＴＯＮ， Ｐ． Ｊ． ｅｔ ａｌ．: 'Ｂｕｄｄｌｅｊａ ａｎｄ Ｗｏｕｎｄ Ｈｅａｌｉｎｇ' ＳＯＦＷ-Ｊｏｕｒｎａｌ Ｖｏｌ．１２３， Ｎｏ．１, 1997, ｐ．４０-４３
JPN6012037817; ＨＯ， Ｊ． Ｎ．: 'Ｐｒｏｔｅｃｔｉｖｅ Ｅｆｆｅｃｔｓ ｏｆ Ａｕｃｕｂｉｎ Ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｅｕｃｏｍｍｉａ ｕｌｍｏｉｄｅｓ ａｇａｉｎｓｔ ＵＶＢ-Ｉｎｄｕｃｅｄ Ｏｘｉｄａｔｉｖｅ Ｓｔｒｅｓｓ ｉ' Ｂｉｏｌ． Ｐｈａｒｍ． Ｂｕｌｌ． Ｖｏｌ．２８， Ｎｏ．７, 2005, ｐ．１２４４-１２４８
Attorney, Agent or Firm:
Ryu Iwatani