Title:
アルキニル化合物の連続製造方法
Document Type and Number:
Japanese Patent JP2528972
Kind Code:
B2
Abstract:
A novel and efficient method is proposed for the synthetic preparation of a long-chain alkynyl compound in a one-pot reaction without isolating the intermediate from the reaction mixture. The inventive method comprises the steps of: (a) a Grignard coupling reaction of an omega -halogeno-1-alkynyl magnesium halide compound of the general formula X<1>MgC IDENTICAL C(CH2)nX<2>, in which X<1> is a halogen atom, X<2> is an atom of Br or I and n is 3 to 10, and a Grignard reagent of the general formula RMgX<1>, in which R is a group selected from the class consisting of alkyl groups, alkenyl groups, alkynyl groups, alkapolyenyl groups, aryl groups and hydrocarbon groups having a protected hydroxy group to give an intermediate compound of the general formula X<1>MgC IDENTICAL C(CH2)nR; (b) subjecting the intermediate compound to a reaction with a reactant selected from the class consisting of C2-synthons, C1-synthons and chlorosilane compounds having reactivity with the intermediate compound at the X<1>Mg-terminal; and (c) hydrolyzing the reaction product obtained in step (b).
Inventors:
山本 昭
福本 毅彦
福本 毅彦
Application Number:
JP24302189A
Publication Date:
August 28, 1996
Filing Date:
September 19, 1989
Export Citation:
Assignee:
信越化学工業株式会社
International Classes:
C07B49/00; C07C29/42; C07C33/042; C07C43/303; C07C59/42; C07C69/145; C07F7/08; C07C41/50; (IPC1-7): C07B49/00; C07C33/042; C07C41/50; C07C43/303; C07C69/145; C07F7/08
Attorney, Agent or Firm:
山本 亮一 （外１名）