Title:
A deciding method of the cancer cell drug susceptibility over aurora kinase inhibitor
Document Type and Number:
Japanese Patent JP6144696
Kind Code:
B2
Abstract:
The present invention relates to a method for determining the sensitivity and/or resistance of a patient suffering from a cancer disease to Aurora kinase inhibitor therapy, which comprises determining in vitro in the cancer cells or body fluids taken from the patient the expression of at least one gene selected from a particular group and/or determining in vitro in the cancer cells or body fluids taken from the patient the level of at least one protein selected from a particular group. Also, the invention relates to a group of compounds which allow overcoming the resistance.
Inventors:
Cola lady, madus dan reddy
Hey Duff, Marian
Jubak, Petr
Slovnar, Joseph
Raba Cova, Rita
Hana, Kovalova
Hey Duff, Marian
Jubak, Petr
Slovnar, Joseph
Raba Cova, Rita
Hana, Kovalova
Application Number:
JP2014545094A
Publication Date:
June 07, 2017
Filing Date:
December 07, 2012
Export Citation:
Assignee:
Paracchi University, Olomouc
Institute of Animal Physiology and Genetics A.S.R., V.V.I.
Institute of Animal Physiology and Genetics A.S.R., V.V.I.
International Classes:
C12Q1/68
Foreign References:
| WO2010088470A1 |
Other References:
Pharmacogenomics J., (2009), 9, [2], p.90-102
Attorney, Agent or Firm:
Harakenzo world patent & trademark