Title:
ＨＰＫ１を標的とするｇＲＮＡ及びＨＰＫ１遺伝子の編集方法
Document Type and Number:
Japanese Patent JP7412666
Kind Code:
B2
Abstract:
Provided is a gRNA targeting HPK1 and a method for editing HPK1 gene. The method can knock out the T cell HPK1 gene, enhance the T cell killing activity, increase the Th1 cytokine level of peripheral blood mononuclear cells, and knock out of the T cell HPK1 gene can also down-regulate the expression of PD-1 and TIM3 on the T cell surface and can inhibit the T cell depletion.
Inventors:
Lio Swepin
Su Jingwen
Su Jingwen
Application Number:
JP2020517124A
Publication Date:
January 15, 2024
Filing Date:
September 20, 2018
Export Citation:
Assignee:
Beijing Senmiao Biological Technology Co., Ltd.
International Classes:
C12N5/078; A61K35/17; A61K48/00; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/06; C12N5/10; C12N15/09; C12N15/86
Foreign References:
| WO2016090300A1 | ||||
| WO2007041511A2 | ||||
| WO2016069282A1 | ||||
| WO2016196388A1 |
Other References:
Immunologic Research,2012,54(1-3),pp.262-265
Nat Immunol.,2007,8(1),pp.84-91
Nat Immunol.,2007,8(1),pp.84-91
Attorney, Agent or Firm:
Maki Seto