Title:
線維症をモジュレートするマイクロＲＮＡファミリー及びその使用
Document Type and Number:
Japanese Patent JP5587777
Kind Code:
B2
Abstract:
The present invention relates to the identification of a microRNA family, designated miR-29a-c, that is a key regulator of fibrosis in cardiac tissue. The inventors show that members of the miR-29 family are down-regulated in the heart tissue in response to stress, and are up-regulated in heart tissue of mice that are resistant to both stress and fibrosis. Also provided are methods of modulating expression and activity of the miR-29 family of miRNAs as a treatment for fibrotic disease, including cardiac hypertrophy, skeletal muscle fibrosis other fibrosis related diseases and collagen loss-related disease.
Inventors:
Orson, Eric
Van, ローイス, Eva
Van, ローイス, Eva
Application Number:
JP2010520206A
Publication Date:
September 10, 2014
Filing Date:
July 31, 2008
Export Citation:
Assignee:
Board オブ リージエンツ, the university オブ Texas system
International Classes:
A61K31/7088; A61K9/51; A61K31/7115; A61K31/712; A61K39/395; A61K47/44; A61P1/16; A61P3/10; A61P9/00; A61P11/00; A61P13/12; A61P17/00; A61P21/00; C12N15/113; A01K67/027; A61K31/7105; A61K45/00; A61K48/00; A61P3/02; A61P9/04; A61P9/10; A61P9/12; C12N5/10; C12N15/09; C12Q1/68
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki