Title:
NOVEL MODULATORS AND METHODS OF USING THE SAME
Document Type and Number:
Japanese Patent JP2018115162
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods, compounds, compositions and articles of manufacture that may be used in treatment of CD46 associated disorders (e.g., hyperproliferative disorders or neoplastic disorders).SOLUTION: The present invention provides novel modulators, including anti-CD46 antibodies and derivatives thereof, and methods of using such modulators in treating hyperproliferative disorders, where the novel CD46 modulators effectively target cancer stem cells and may be used to treat patients suffering from a variety of malignancies. The disclosed CD46 modulators may comprise any compound that recognizes, competes with, agonizes, antagonizes, interacts with, binds to or associates with the CD46 polypeptide, its ligand or its gene and modulates, adjusts, alters, changes or modifies the CD46 protein on one or more physiological pathways.SELECTED DRAWING: None
Inventors:
SCOTT J DYLLA
FOORD ORIT
ROBERT A STULL
WADE C ANDERSON
OHSHIMA SAIYOU
FOORD ORIT
ROBERT A STULL
WADE C ANDERSON
OHSHIMA SAIYOU
Application Number:
JP2018014408A
Publication Date:
July 26, 2018
Filing Date:
January 31, 2018
Export Citation:
Assignee:
ABBVIE STEMCENTRX LLC
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P35/04; A61P43/00; C07K14/705; C12N15/09
Domestic Patent References:
| JP2005511525A | 2005-04-28 | |||
| JP2006513203A | 2006-04-20 | |||
| JPH0445796A | 1992-02-14 | |||
| JP2013539966A | 2013-10-31 |
Foreign References:
| WO2002018948A2 | 2002-03-07 | |||
| WO2009126558A1 | 2009-10-15 |
Other References:
MANCHESTER, M. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 92, JPN6015033573, 1995, pages 2303 - 2307, ISSN: 0003945906
LISZEWSKI, M.K. ET AL., ANNU. REV. IMMUNOL., vol. 9, JPN6015033576, 1991, pages 431 - 455, ISSN: 0003945907
HARRIS, C.L. ET AL., J. IMMUNOL. METHODS, vol. 268, JPN6015033579, 2002, pages 245 - 258, ISSN: 0003945908
JURIANZ, K. ET AL., IMMUNOPHARMACOLOGY, vol. 42, JPN6015033582, 1999, pages 209 - 218, ISSN: 0003945909
LISZEWSKI, M.K. ET AL., ANNU. REV. IMMUNOL., vol. 9, JPN6015033576, 1991, pages 431 - 455, ISSN: 0003945907
HARRIS, C.L. ET AL., J. IMMUNOL. METHODS, vol. 268, JPN6015033579, 2002, pages 245 - 258, ISSN: 0003945908
JURIANZ, K. ET AL., IMMUNOPHARMACOLOGY, vol. 42, JPN6015033582, 1999, pages 209 - 218, ISSN: 0003945909
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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