Title:
2型糖尿病治療薬を同定するための、新規なAS160様タンパク質、それを伴なうテストシステム、方法及び使用
Document Type and Number:
Japanese Patent JP2010534482
Kind Code:
A
Abstract:
The present invention relates to novel AKT substrate 160kDa-like protein (AS160-like protein), to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160kDa-like protein (AS160-like protein) with a test substance, and identifying a test substance as a substance altering glucose uptake of a cell by detecting a signal indicative for altered glucose uptake of a cell; a test system comprising a gene coding for the AKT substrate 160 kDa-like protein (AS160-like protein) and an inducible promoter providing for controllable expression of the gene; the use of the test system for the identification of a substance improving glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell; and the use of AS160-like protein in a model for type 2 diabetes.
Inventors:
Norbert Tenagels
Danilla Baos
Katrin Halemeier
Werner Dittlich
Danilla Baos
Katrin Halemeier
Werner Dittlich
Application Number:
JP2010518539A
Publication Date:
November 11, 2010
Filing Date:
July 23, 2008
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
C12Q1/02; C07K14/47; C07K16/18; C12N5/10; C12N15/09; G01N33/15; G01N33/50; G01N37/00
Foreign References:
| WO2006099005A1 | 2006-09-21 |
Other References:
JPN6013015659; Ｃｅｌｌ Ｍｅｔａｂｏｌｉｓｍ， （２００７ Ａｐｒｉｌ）， Ｖｏｌ．５， ｐ． ２３７-２５２
JPN6013015662; Ｂｉｏｃｈｅｍ． Ｊ．， （２００７ Ｆｅｂｒｕａｒｙ）， Ｖｏｌ． ４０３， ｐ． ３５３-３５８
JPN6013015664; Ｂｉｏｃｈｅｍ． Ｊ．， （２００５）， Ｖｏｌ． ３９１， ｐ． ８７-９３
JPN6013015662; Ｂｉｏｃｈｅｍ． Ｊ．， （２００７ Ｆｅｂｒｕａｒｙ）， Ｖｏｌ． ４０３， ｐ． ３５３-３５８
JPN6013015664; Ｂｉｏｃｈｅｍ． Ｊ．， （２００５）， Ｖｏｌ． ３９１， ｐ． ８７-９３
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi