Title:
新規な遷移金属錯体、及び該錯体を用いた光学活性アルコールの製造法
Document Type and Number:
Japanese Patent JP4590353
Kind Code:
B2
Abstract:
A novel transition metal complex, preferably a ruthenium-phosphine complex or rhodium-phosphine complex, which is effectively usable in various asymmetric syntheses and, in particular, is more effectively usable in the asymmetric hydrogenation of various ketones; and a novel process for producing an optically active alcohol with the complex. The novel transition metal complex includes a ligand obtained by introducing a diarylphosphino group into each of the 2- and 2'-positions of diphenyl ether, benzophenone, benzhydrol, or the like. It preferably further includes an optically active 1,2-diphenylethylenediamine coordinated thereto. The complex preferably is a novel diphosphine-ruthenium-optically active diamine complex or diphosphine-rhodium-optically active diamine complex. The process comprises using the complex as an asymmetric hydrogenation catalyst to conduct the asymmetric hydrogenation of a ketone compound to thereby obtain an optically active alcohol in a high optical purity and a high yield.
Inventors:
Koichi Mikami
Noboru Sayo
Noboru Sayo
Application Number:
JP2005513186A
Publication Date:
December 01, 2010
Filing Date:
August 13, 2004
Export Citation:
Assignee:
Takasago International Corporation
International Classes:
C07F9/50; B01J31/18; B01J31/24; C07B53/00; C07C29/145; C07C33/22; C07C211/27; C07C211/65; C07F9/655; C07F15/00; C07B61/00
Domestic Patent References:
| JP2002308816A | 2002-10-23 | |||
| JP2003252884A | 2003-09-10 |
Foreign References:
| WO2001074829A1 | 2001-10-11 |
Attorney, Agent or Firm:
Norio Saeki