Title:
The polymyxin derivative which has a tail part of short chain fatty acid, and its use
Document Type and Number:
Japanese Patent JP6050854
Kind Code:
B2
Abstract:
The present invention relates to a polymyxin derivative wherein the derivative has a total of three positive charges at physiological pH and wherein the terminal moiety (D) of the derivative comprises a total of 1 to 5 carbon atoms; and to a combination product comprising at least two such derivatives. The invention further relates to a method for sensitizing Gram-negative bacteria to an antibacterial agent by administering, simultaneously or sequentially in any order a therapeutically effective amount of said antibacterial agent and a derivative according to the present invention to said subject; to methods for developing novel antibiotics; and for sensitizing clinically important bacteria to a host defense mechanism complement present in serum. The invention also relates to a method of treating a subject for a gram-negative bacterial infection by administering a polymyxin derivative of the invention in combination with a second antibacterial agent. Finally, the invention relates to a process for preparing such polymyxin derivatives.
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Inventors:
Martti Varra
Timo Vara
Timo Vara
Application Number:
JP2015072612A
Publication Date:
December 21, 2016
Filing Date:
March 31, 2015
Export Citation:
Assignee:
Northern Antibiotics Oy
International Classes:
C07K7/62; A61K38/00; A61P31/04; A61P43/00; C07K1/107
Domestic Patent References:
| JP5752421B2 |
Foreign References:
| WO2006083317A1 | ||||
| US20060004185 | ||||
| US4485039 |
Other References:
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2007年,Vol. 80, No. 3,pp. 543-552
JOURNAL OF MEDICINAL CHEMISTRY,2000年,Vol. 43, No. 16,pp. 3085-3092
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2004年,Vol. 77,pp. 1915-1924
CHEMICAL & PHARMACEUTICAL BULLETIN,2007年,Vol. 55, No. 12,pp. 1724-1730
JOURNAL OF PEPTIDE RESEARCH,2003年,Vol. 61, No. 6,pp. 298-306
PEPTIDES,2001年,Vol. 22, No. 10,pp. 1675-1681
JOURNAL OF MEDICINAL CHEMISTRY,2000年,Vol. 43, No. 16,pp. 3085-3092
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN,2004年,Vol. 77,pp. 1915-1924
CHEMICAL & PHARMACEUTICAL BULLETIN,2007年,Vol. 55, No. 12,pp. 1724-1730
JOURNAL OF PEPTIDE RESEARCH,2003年,Vol. 61, No. 6,pp. 298-306
PEPTIDES,2001年,Vol. 22, No. 10,pp. 1675-1681
Attorney, Agent or Firm:
Kenji Sugimura
Yoshikazu Takagi
Yoshikazu Takagi