光学活性アルコ−ルの製造方法

Japanese Patent JPH064544

B2

A carbonyl compound represented by the formula: wherein A represents C1-7 alkyl or haloalkyl, optionally substituted phenyl, or optionally substituted benzyl; and B represents C1-4 acyl, C1-7 alkoxycarbonyl, haloalkyl, hydroxycarbonyl, C1-7 alkoxyalkyl, hydroxymethyl, optionally substituted benzoyl or C1-7 alkyl-substituted aminomethyl; or A and B with the adjacent C atom form an optionally substituted cyclic 5- or 6-membered 1,2-diketone, is dissolved in amphiprotic solvent and there is added 100-1/50,000 mol of a ruthenium-optically active phosphine derivative as catalyst, e.g. of formula RuxHyClz(R-BINAP)2-(S)p (III) or [RuH1(R-BINAP)v]Yw (V) wherein BINAP is a specific tertiary phosphine group. The compound (I) is reacted with hydrogen at a pressure of 5-40 kg/cm<2> for 1-48 hours and there is recovered in high yield as product an optically active alcohol of the formula (II) wherein the =C=O group has become =CH-OH.

JP2785363	[Title of Invention] Method for Purifying Lactones
WO/2005/021487	CATHEPSIN INHIBITORS
JP3031701	Description: Lactone compound and composition

SAYO NOBORU
KUMOBAYASHI HIDENORI
AKUTAGAWA SUSUMU
NOYORI RYOJI
TAKATANI HIDEMASA

JP15248387A

January 19, 1994

June 19, 1987

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TAKASAGO PERFUMERY CO LTD

C07D307/33; B01J31/24; C07B31/00; C07B41/02; C07B53/00; C07B61/00; C07C27/00; C07C29/145; C07C31/20; C07C31/36; C07C33/26; C07C35/06; C07C35/08; C07C41/00; C07C41/26; C07C43/13; C07C43/178; C07C51/00; C07C51/367; C07C59/01; C07C59/50; C07C67/00; C07C67/31; C07C213/00; C07C215/08; (IPC1-7): C07B41/02; B01J31/24; C07B53/00; C07C31/20; C07C31/36; C07C33/26; C07C35/06; C07C35/08; C07C43/13; C07C43/178; C07C51/367; C07C59/01; C07C59/50; C07C67/31; C07C215/08; C07D307/33

JPS491505A

有賀 三幸 （外２名）

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