Title:
The solid medicine constituent containing integrase inhibitor
Document Type and Number:
Japanese Patent JP6122639
Kind Code:
B2
Abstract:
Compressed tablets for oral administration containing raltegravir in the form of a pharmaceutically acceptable salt are described. The tablets comprise (A) an intragranular component comprising (i) an effective amount of an alkali metal salt of raltegravir, (ii) optionally a first superdisintegrant, and (iii) a binder; and (B) an extragranular component comprising (i) a second superdisintegrant, (ii) a filler, and (iii) a lubricant. Methods for preparing the tablets and the use of the tablets, optionally in combination with other anti-HIV agents, for the inhibition of HIV integrase, for the treatment or prophylaxis of HIV infection, or for the treatment, delay in the onset, or prophylaxis of AIDS are also described.
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Inventors:
Majjor, Masjid
Lee, Huon
Ma, Douchyuyeon
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Lee, Huon
Ma, Douchyuyeon
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Application Number:
JP2012535360A
Publication Date:
April 26, 2017
Filing Date:
October 21, 2010
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
A61K31/513; A61K9/20; A61K9/24; A61K47/02; A61K47/10; A61K47/12; A61K47/14; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P31/18; A61P43/00
Domestic Patent References:
| JP2008521929A |
Foreign References:
| WO2008043167A1 | ||||
| WO2009054743A1 | ||||
| WO2009002823A1 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
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