Title:
The system which uses imaging contrast media and imaging contrast media
Document Type and Number:
Japanese Patent JP6184327
Kind Code:
B2
Abstract:
Bubbles (118-122) are utilized in some embodiments as part of a photoacoustic contrast agent (162) and, in some embodiments, to localize one or more locations (126-38) of a source of acoustic energy. The bubbles, such as microbubbles, can be used in proximity of nanoparticles of a first photoacoustic contrast agent, thereby affording a second photoacoustic contrast agent. The bubbles can intercept and re-radiate acoustic energy emitted by light-based activation of the first photoacoustic contrast agent in the immediate vicinity of the bubbles. As a further option, if the nanoparticles permeate further to tissue structures but remain in close enough proximity, their positions can be triangulated by the nearby bubbles, based on direction (144-148) and time delays (150-160) of ultrasound received by a transducer array.
Inventors:
Sea William Tao
Jankovic Ladislav
Jankovic Ladislav
Application Number:
JP2013545552A
Publication Date:
August 23, 2017
Filing Date:
December 12, 2011
Export Citation:
Assignee:
KONINKLIJKE PHILIPS N.V.
International Classes:
A61B8/00; A61B8/13; A61K49/00
Domestic Patent References:
| JP2002537933A | ||||
| JP2002514456A | ||||
| JP2002508760A | ||||
| JP2009540904A | ||||
| JP2008519642A |
Foreign References:
| WO2009057021A2 |
Attorney, Agent or Firm:
Fueda Shusen