Title:
ジアミノトリフルオロメチルピリジン誘導体を含有する肺不全の治療剤又は予防剤
Document Type and Number:
Japanese Patent JP4848092
Kind Code:
B2
Abstract:
A therapeutic or preventive agent for pulmonary insufficiency, containing as an active ingredient a diaminotrifluoromethylpyridine derivative represented by the formula (I) or its salt: wherein X is a -CW<1>R<1> group, a -COCOR<2> group, a -CW<1>NHCOR<2> group, a -C(=W<1>)W<2>R<3> group or a -CW<1>N(R<4>)R<5> group; Y is an alkyl group, a -CW<3>R<6> group, a -COCOR<7> group, a -NHCOR<7> group, a -C(=W<3>)W<4>R<8> group, a -(NH)mSO2R<9> group, a -(NH)mSO2OR<10> group or a -(NH)mSO2N(R<11>)R<12> group; each of R<1>, R<6> and R<9> is a chain hydrocarbon group, a monocyclic hydrocarbon group, a polycyclic hydrocarbon group, a monocyclic heterocycle group or a polycyclic heterocycle group; each of R<2> and R<7> is an alkyl group, an alkoxy group, a phenyl group or a phenoxy group; each of R<3>, R<8> and R<10> is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a phenyl group or a benzyl group; each of R<4>, R<5>, R<11> and R<12> is an alkyl group; each of W<1>, W<2>, W<3> and W<4> is an oxygen atom or a sulfur atom; and m is 0 or 1, is provided.
Inventors:
Morino Hisaya
Yoichi
Tadashi Imamura
Yoichi
Tadashi Imamura
Application Number:
JP2001020057A
Publication Date:
December 28, 2011
Filing Date:
January 29, 2001
Export Citation:
Assignee:
Ishihara Sangyo Co., Ltd.
International Classes:
A61K31/44; C07D213/75; A61K31/435; A61K31/4433; A61K31/4436; A61K31/4439; A61P11/00; C07D213/00; C07D213/76; C07D409/12; A61K; A61P; C07D
Domestic Patent References:
| JP6263735A |
Other References:
TOUQUI, L.,A role for phospholipase A2 in ARDS pathogenesis,Molecular Medicine Today,1999年,5(6),p. 244-249
FURUE, S.,Crucial role of group IIA phospholipase A2 in oleic acid-induced acute lung injury in rabbits,American Journal of Respiratory and Critical Care Medicine,1999年,160(4),p. 1292-1302
ARBIBE, L.,Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction,Journal of Clinical Investigation,1998年,102(6),p. 1152-1160
BOWTON, D. L.,Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics,American Journal of Respiratory and Critical Care Medicine,1997年,155(2),p. 421-425
HIDI, R.,Inhibition by pulmonary surfactant Curosurf of secretory phospholipase A2 expression in guinea-pig alveolar macrophages,Biochemical Pharmacology,1997年,54(9),p. 1055-1058
FURUE, S.,Crucial role of group IIA phospholipase A2 in oleic acid-induced acute lung injury in rabbits,American Journal of Respiratory and Critical Care Medicine,1999年,160(4),p. 1292-1302
ARBIBE, L.,Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction,Journal of Clinical Investigation,1998年,102(6),p. 1152-1160
BOWTON, D. L.,Phospholipase A2 and arachidonate increase in bronchoalveolar lavage fluid after inhaled antigen challenge in asthmatics,American Journal of Respiratory and Critical Care Medicine,1997年,155(2),p. 421-425
HIDI, R.,Inhibition by pulmonary surfactant Curosurf of secretory phospholipase A2 expression in guinea-pig alveolar macrophages,Biochemical Pharmacology,1997年,54(9),p. 1055-1058