Title:
THERAPEUTIC PROTEINS WITH INCREASED HALF-LIFE AND METHODS OF PREPARING THE SAME
Document Type and Number:
Japanese Patent JP2021183636
Kind Code:
A
Abstract:
To provide materials and methods for conjugating a water soluble polymer to a therapeutic protein.SOLUTION: A method of preparing a therapeutic protein conjugate comprises the step of contacting a therapeutic protein or a biologically-active fragment thereof with a thiol reductant and a water soluble polymer, or functional derivatives thereof, under conditions that (a) a reduced cysteine sulfhydryl group is produced on the therapeutic protein and (b) the conjugation of the water-soluble polymer to the reduced cysteine sulfhydryl group is allowed. The therapeutic protein has an amino acid sequence with no more than one accessible cysteine sulhydryl group.SELECTED DRAWING: None
Inventors:
SIEKMANN JUERGEN
ALFRED WEBER
HANSPETER ROTTENSTEINER
TURECEK PETER
ALFRED WEBER
HANSPETER ROTTENSTEINER
TURECEK PETER
Application Number:
JP2021134697A
Publication Date:
December 02, 2021
Filing Date:
August 20, 2021
Export Citation:
Assignee:
BAXALTA GMBH
BAXALTA INC
BAXALTA INC
International Classes:
A61K38/16; A61K38/36; A61K38/43; A61K38/55; A61K47/34; A61K47/36; A61K47/60
Domestic Patent References:
| JP2007527891A | 2007-10-04 | |||
| JP2002534119A | 2002-10-15 | |||
| JP2009513643A | 2009-04-02 | |||
| JP2008524117A | 2008-07-10 |
Other References:
DATABASE REGISTRY, vol. RN 1184691-59-5, JPN6018008363, 15 September 2009 (2009-09-15), ISSN: 0005082502
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Hidetoshi Hanai
Satoko Tsuruta
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Hidetoshi Hanai
Satoko Tsuruta
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