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Title:
A treatment for a viscosity supplement in a joint
Document Type and Number:
Japanese Patent JP6139716
Kind Code:
B2
Abstract:
The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc „¢ ) is administered in a single intra-articular knee injection of 6 ± 2 ml.

Inventors:
Bayreul Francois
Application Number:
JP2016010289A
Publication Date:
May 31, 2017
Filing Date:
January 22, 2016
Export Citation:
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Assignee:
GENZYME CORPORATION
International Classes:
A61K31/728; A61K9/08; A61P19/02
Domestic Patent References:
JP2001500472A
JP99059603A1
Other References:
CONROZIER THIERRY,JOINT,BONE,SPINE,2003年 3月,V70 N2,P128-133
LUSSIER A,JOURNAL OF RHEUMATOLOGY,カナダ,1996年 9月 1日,V23 N9,P1579-1585
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi