Title:
A wrench viral vector containing a MHC class I promotor
Document Type and Number:
Japanese Patent JP5938143
Kind Code:
B2
Abstract:
The present invention relates to the insertion of a promoter sequence from an MHC class I gene promoter into a lentiviral vector in order to direct the transcription of a transgene, which preferably encodes an immunogenic polypeptide to be expressed in a mammalian host cell, preferably APC (DCs). The invention encompasses these vectors, methods of making the vectors, and methods of using them, including medicinal uses.
Inventors:
Surrey, Emeryne
Bosch, Cecil
Bosch, Cecil
Application Number:
JP2015513076A
Publication Date:
June 22, 2016
Filing Date:
April 30, 2013
Export Citation:
Assignee:
THERAVECTYS
International Classes:
C12N15/09; A61K35/76; A61K39/00; A61K39/21; A61K48/00; A61P31/18; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01
Other References:
KIMURA, Takahiro et al.,"Lentiviral Vectors with CMV or MHCII Promoters Administered In Vivo: Immune Reactivity Versus Persistence of Expression",Mol. Ther.,2007年,Vol. 15,p. 1390-1399
LOPES, Luciene et al.,"Immunization with a Lentivector That Targets Tumor Antigen Expression to Dendritic Cells Induces Potent CD8+ and CD4+ T-Cell Responses",J. Virol.,2008年,Vol. 82,p. 86-95
CHINNASAMY, Nachimuthu et al.,"Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors",Hum. Gene Ther.,2000年,Vol. 11,p. 1901-1909
LOPES, Luciene et al.,"Immunization with a Lentivector That Targets Tumor Antigen Expression to Dendritic Cells Induces Potent CD8+ and CD4+ T-Cell Responses",J. Virol.,2008年,Vol. 82,p. 86-95
CHINNASAMY, Nachimuthu et al.,"Efficient gene transfer to human peripheral blood monocyte-derived dendritic cells using human immunodeficiency virus type 1-based lentiviral vectors",Hum. Gene Ther.,2000年,Vol. 11,p. 1901-1909
Attorney, Agent or Firm:
Naoto Uchida