Title:
1,4-BENZODIAZEPIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2000073284
Kind Code:
A3
Abstract:
The present invention relates to 1,4-benzodiazepin-2-ones of Formula (I) or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
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Inventors:
RODGERS JAMES D
JOHNSON BARRY L
WANG HAISHENG
JOHNSON BARRY L
WANG HAISHENG
Application Number:
PCT/US2000/014001
Publication Date:
April 05, 2001
Filing Date:
May 19, 2000
Export Citation:
Assignee:
DU PONT PHARM CO (US)
International Classes:
A61P31/18; C07D243/14; C07D401/06; C07D405/06; C07D409/06; C07D417/06; (IPC1-7): C07D243/14; C07D243/24; C07D401/06; C07D405/06; C07D409/06; C07D417/06; A61K31/5513; A61P31/18
Domestic Patent References:
| WO1996029329A1 | 1996-09-26 | |||
| WO1995012583A1 | 1995-05-11 | |||
| WO1995013273A1 | 1995-05-18 |
Foreign References:
| US3682892A | 1972-08-08 | |||
| US3714145A | 1973-01-30 | |||
| US3864330A | 1975-02-04 | |||
| US3801569A | 1974-04-02 | |||
| US4021421A | 1977-05-03 | |||
| US4045433A | 1977-08-30 | |||
| US4316897A | 1982-02-23 | |||
| EP0530994A1 | 1993-03-10 | |||
| DE4320347A1 | 1994-12-22 | |||
| US5519021A | 1996-05-21 |
Other References:
HOUPIS I N ET AL: "SYNTHESIS OF A NEW GENERATION REVERSE TRANSCRIPTASE INHIBITOR VIA THE BCl3/GACl3-INDUCED CONDENSATION OF ANILINES WITH NITRILES (SUGASAWA REACTION)", TETRAHEDRON LETTERS,NL,ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, vol. 35, no. 37, 1994, pages 6811 - 6814, XP002072025, ISSN: 0040-4039
TUCKER T J ET AL: "SYNTHESIS OF A SERIES OF 4-(ARYLETHYNYL)-6-CHLORO-4-CYCLOPROPYL- 3,4-D IGYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NON-NUCLEOSIDE HIV-1 REVERSETRANSCRIPTASE INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 37, no. 15, 1994, pages 2437 - 2444, XP002072024, ISSN: 0022-2623
HUFFMAN M A ET AL: "LITHIUM ALKOXIDES OF CINCHONA ALKALOIDS AS CHIRAL CONTROLLERS FOR ENANTIOSELECTIVE ACETYLIDE ADDITION TO CYCLIC N-ACYL KETIMINES", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 60, no. 6, 1995, pages 1590 - 1594, XP002072026, ISSN: 0022-3263
TUCKER T J ET AL: "SYNTHESIS OF A SERIES OF 4-(ARYLETHYNYL)-6-CHLORO-4-CYCLOPROPYL- 3,4-D IGYDROQUINAZOLIN-2(1H)-ONES AS NOVEL NON-NUCLEOSIDE HIV-1 REVERSETRANSCRIPTASE INHIBITORS", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 37, no. 15, 1994, pages 2437 - 2444, XP002072024, ISSN: 0022-2623
HUFFMAN M A ET AL: "LITHIUM ALKOXIDES OF CINCHONA ALKALOIDS AS CHIRAL CONTROLLERS FOR ENANTIOSELECTIVE ACETYLIDE ADDITION TO CYCLIC N-ACYL KETIMINES", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 60, no. 6, 1995, pages 1590 - 1594, XP002072026, ISSN: 0022-3263
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