2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY

Title:

2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY

Document Type and Number:

WIPO Patent Application WO2000040569

Kind Code:

A8

Abstract:

The use of a compound comprising formula (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R<1> is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

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Inventors:

HODSON HAROLD FRANCIS (GB)
DOWNHAM ROBERT (GB)
MITCHELL TIMOTHY JOHN (GB)
CARR BEVERLEY JANE (GB)
DUNK CHRISTOPHER ROBERT (GB)
PALMER RICHARD MICHAEL JOHN (GB)

Application Number:

PCT/GB2000/000031

Publication Date:

June 28, 2001

Filing Date:

January 06, 2000

Export Citation:

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Assignee:

ALIZYME THERAPEUTICS LTD (GB)
HODSON HAROLD FRANCIS (GB)
DOWNHAM ROBERT (GB)
MITCHELL TIMOTHY JOHN (GB)
CARR BEVERLEY JANE (GB)
DUNK CHRISTOPHER ROBERT (GB)
PALMER RICHARD MICHAEL JOHN (GB)

International Classes:

A61J3/00; A61J3/02; A61J3/06; A61J3/07; A61K31/536; A61K31/5365; A61P1/00; A61P3/00; A23L1/30; A61P3/04; A61P3/06; A61P3/10; A61P9/00; A61P9/10; A61P9/12; A61P43/00; C07C271/28; C07C271/58; C07D265/24; C07D265/26; C07D413/12; C07D498/04; C12N9/99; (IPC1-7): C07D265/24; C07D498/04; C07D413/12; A61K31/536; A61P3/04

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