2- [ ISOQUINOLIN-S - CARBONYL ) AMINO] -PROPIONIC ACID DERIVATIVES AS INHIBITORS OF FACTORS XI AND IX FOR THE TREATMENT OF THROMBOSIS

Title:

2- [ ISOQUINOLIN-S - CARBONYL ) AMINO] -PROPIONIC ACID DERIVATIVES AS INHIBITORS OF FACTORS XI AND IX FOR THE TREATMENT OF THROMBOSIS

Document Type and Number:

WIPO Patent Application WO2006093823

Kind Code:

A9

Abstract:

This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor Xl and thus, may be used to inhibit the intrinsic pathway of blood coagulation. Formula (X) wherein R₁₀₂ is selected from the group consisting of -C(O)OH, -C(O)OCH₃, -C(O)O-t-butyl, -C(O)NH-OCH₂-phenyl, C(O)NHOH, and -C(O)NHSO₂CH₃; and wherein R₁₀₁ .R₁₀₃,R₁₀₄ and Y are as defined herein.

Inventors:

MJALLI ADNAN M M (US)
GOHIMMUKKULA DEVI REDDY (US)
TYAGI SAMEER (US)

Application Number:

PCT/US2006/006571

Publication Date:

November 02, 2006

Filing Date:

February 23, 2006

Export Citation:

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Assignee:

TRANSTECH PHARMA INC (US)
MJALLI ADNAN M M (US)
GOHIMMUKKULA DEVI REDDY (US)
TYAGI SAMEER (US)

International Classes:

C07D409/12; A61K31/4725; A61P7/02; A61P9/00; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07C237/36; C07C237/42; C07C271/20; C07C311/08; C07C311/09; C07C311/21; C07C311/44; C07C317/32; C07C323/36; C07D217/26; C07D295/155; C07D407/12

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