2-METHYLPROPIONIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Title:

2-METHYLPROPIONIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO/1999/052856

Kind Code:

A1

Abstract:

Novel 2-methylpropionic acid derivatives represented by general formula (I) and pharmacologically acceptable salts thereof which have an excellent $g(b)¿3? adrenaline receptor stimulating effect and are useful as preventives or remedies for obesity, hyperglycemia, diseases caused by accelerated intestinal motion, frequent urination, urinary incontinence, depression, cholelithiasis or diseases caused by accelerated biliary motion. In said Formula (I) R?1¿ represents hydrogen, lower alkyl or aralkyl; R?2¿ represents hydrogen, lower alkyl or halogeno; A represents oxygen or imino; the carbon atom to which (R) is attached stands for one with the R-configuration; and the carbon atom to which (S) is attached stands for one with the S-configuration.

Inventors:

TAMAI TETSURO (JP)
TANAKA NOBUYUKI (JP)
MUKAIYAMA HARUNOBU (JP)
HIRABAYASHI AKIHITO (JP)
MURANAKA HIDEYUKI (JP)
SATO MASAAKI (JP)
AKAHANE MASUO (JP)

Application Number:

PCT/JP1999/001836

Publication Date:

October 21, 1999

Filing Date:

April 07, 1999

Export Citation:

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Assignee:

KISSEI PHARMACEUTICAL (JP)
TAMAI TETSURO (JP)
TANAKA NOBUYUKI (JP)
MUKAIYAMA HARUNOBU (JP)
HIRABAYASHI AKIHITO (JP)
MURANAKA HIDEYUKI (JP)
SATO MASAAKI (JP)
AKAHANE MASUO (JP)

International Classes:

C07C217/60; C07C229/18; (IPC1-7): C07C217/60; C07C229/18; A61K31/19; A61K31/22

Domestic Patent References:

WO1999005090A1	1999-02-04
WO1998013333A1	1998-04-02

Foreign References:

JPS565444A

1981-01-20

Other References: