Title:
2-METHYLTHIAZOLIDINE-2,4-DICARBOXYLIC ACID-CONTAINING COMBINATION PREPARATIONS
Document Type and Number:
WIPO Patent Application WO2005105062
Kind Code:
A3
Abstract:
The invention relates to a combination preparation from 2-methylthiazolidine-2,4-dicarboxylic acid and/or the physiologically acceptable salts of said compound and at least one anti-angiogenic and/or cytotoxic and/or cytostatic compound. The invention also relates to the use of said combination preparations in the treatment of cancer.
Inventors:
SUSILO RUDY (DE)
AMTMANN EBERHARD (DE)
AMTMANN EBERHARD (DE)
Application Number:
PCT/DE2005/000810
Publication Date:
February 23, 2006
Filing Date:
May 02, 2005
Export Citation:
Assignee:
SUSILO RUDY (DE)
AMTMANN EBERHARD (DE)
AMTMANN EBERHARD (DE)
International Classes:
A61K31/425; A61K31/00; A61P35/00
Domestic Patent References:
| WO2001060343A2 | 2001-08-23 |
Foreign References:
| FR2133508A1 | 1972-12-01 |
Other References:
WLODEK ET AL: "2-Methyl-thiazolidine-2,4-dicarboxylic acid protects against paracetamol induced toxicity in human liver derived HepG2 cells", ACTA BIOCHIMICA POLONICA, POLISH SCIENTIFIC PUBLISHERS, WARSAW, PO, vol. 4, no. 44, October 1997 (1997-10-01), pages 759 - 66, XP002075765, ISSN: 0001-527X
SOKOLOWSKA, MARIA ET AL: "Protective effect of .alpha.-keto acids on the oxidative hemolysis", POLISH JOURNAL OF PHARMACOLOGY , 51(5), 429-434 CODEN: PJPAE3; ISSN: 1230-6002, 1999, XP008057282
WLODEK, L. ET AL: "2-Methyl-thiazolidine-2,4-dicarboxylic acid as prodrug of L-cysteine. Protection against paracetamol hepatotoxicity in mice", FUNDAMENTAL & CLINICAL PHARMACOLOGY , 11(5), 454-459 CODEN: FCPHEZ; ISSN: 0767-3981, 1997, XP008057290
WLODEK L: "Biological properties of 2-methyl-thiazolidine-2,4-dicarboxylic acid, the product of nonenzymatic condensation of L-cysteine with pyruvate", AMINO ACIDS (VIENNA), vol. 17, no. 1, 1999, & 6TH INTERNATIONAL CONGRESS ON AMINO ACIDS; BONN, GERMANY; AUGUST 3-7, 1999, pages 71, XP008057284, ISSN: 0939-4451
WLODEK, LIDIA ET AL: "The modulation of IL-2 dependent proliferation of CTLL-2 cells by 2-methyl-thiazolidine-2,4-dicarboxylic acid", IMMUNOPHARMACOLOGY , 30(1), 51-8 CODEN: IMMUDP; ISSN: 0162-3109, 1995, XP008057299
SOKOLOWSKA, MARIA ET AL: "Protective effect of .alpha.-keto acids on the oxidative hemolysis", POLISH JOURNAL OF PHARMACOLOGY , 51(5), 429-434 CODEN: PJPAE3; ISSN: 1230-6002, 1999, XP008057282
WLODEK, L. ET AL: "2-Methyl-thiazolidine-2,4-dicarboxylic acid as prodrug of L-cysteine. Protection against paracetamol hepatotoxicity in mice", FUNDAMENTAL & CLINICAL PHARMACOLOGY , 11(5), 454-459 CODEN: FCPHEZ; ISSN: 0767-3981, 1997, XP008057290
WLODEK L: "Biological properties of 2-methyl-thiazolidine-2,4-dicarboxylic acid, the product of nonenzymatic condensation of L-cysteine with pyruvate", AMINO ACIDS (VIENNA), vol. 17, no. 1, 1999, & 6TH INTERNATIONAL CONGRESS ON AMINO ACIDS; BONN, GERMANY; AUGUST 3-7, 1999, pages 71, XP008057284, ISSN: 0939-4451
WLODEK, LIDIA ET AL: "The modulation of IL-2 dependent proliferation of CTLL-2 cells by 2-methyl-thiazolidine-2,4-dicarboxylic acid", IMMUNOPHARMACOLOGY , 30(1), 51-8 CODEN: IMMUDP; ISSN: 0162-3109, 1995, XP008057299
Download PDF:
Previous Patent: TRANSDERMAL PATCH
Next Patent: PHARMACEUTICAL COMPOSITIONS CONTAINING SERMS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Next Patent: PHARMACEUTICAL COMPOSITIONS CONTAINING SERMS FOR THE TREATMENT OF ALZHEIMER'S DISEASE