Title:
25869, A HUMAN CARBOXYLESTERASE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002002760
Kind Code:
A3
Abstract:
The invention provides isolated nucleic acid molecules, designated COE-1 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-1 gene has been introduced or disrupted. The invention still further provides isolated COE-1 proteins, fusion proteins, antigenic peptides and anti-COE-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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Inventors:
CURTIS RORY A J (US)
LOGAN THOMAS JOSEPH (US)
LOGAN THOMAS JOSEPH (US)
Application Number:
PCT/US2001/020968
Publication Date:
August 15, 2002
Filing Date:
June 29, 2001
Export Citation:
Assignee:
MILLENNIUM PHARM INC (US)
CURTIS RORY A J (US)
LOGAN THOMAS JOSEPH (US)
CURTIS RORY A J (US)
LOGAN THOMAS JOSEPH (US)
International Classes:
C12N9/18; A61K38/00; (IPC1-7): C12N15/55; C12N15/62; C12N9/18; C12N5/10; C12N1/21; C12Q1/68; G01N33/53; G01N33/573
Domestic Patent References:
| WO2000028045A2 | 2000-05-18 | |||
| WO1999042593A1 | 1999-08-26 |
Other References:
DATABASE EMBL [online] EBI; 22 February 2000 (2000-02-22), SUGANO S ET AL.: "Homo sapiens cDNA FLJ20098 fis, clone COL04537, highly similar to ESTM_MOUSE LIVER CARBOXYLESTERASE PRECURSOR", XP002198768, Database accession no. AK000105
DATABASE EMBL [online] EBI; 4 October 1993 (1993-10-04), AIDA K ET AL.: "carboxylesterase [mice, liver, Balb/cj X DBA/2J, mRNA, 2007 nt]", XP002198769, Database accession no. S64130
SATOH T ET AL.: "Molecular aspects of carboxylesterase isoforms in comparison with other esterases", TOXICOLOGY LETTERS, vol. 82/83, 1995, pages 439 - 445, XP001053079, ISSN: 0378-4274
DATABASE EMBL [online] EBI; 4 October 1993 (1993-10-04), AIDA K ET AL.: "carboxylesterase [mice, liver, Balb/cj X DBA/2J, mRNA, 2007 nt]", XP002198769, Database accession no. S64130
SATOH T ET AL.: "Molecular aspects of carboxylesterase isoforms in comparison with other esterases", TOXICOLOGY LETTERS, vol. 82/83, 1995, pages 439 - 445, XP001053079, ISSN: 0378-4274
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