3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS

Title:

3-(2-AMINO-1-AZACYCLYL)-5-ARYL-1,2,4-OXADIAZOLES AS S1P RECEPTOR AGONISTS

Document Type and Number:

WIPO Patent Application WO2004103279

Kind Code:

A3

Abstract:

The present invention encompasses compounds of Formula (I): as well as the pharmaceutically acceptable salts thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.

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Inventors:

COLANDREA VINCENT J (US)
DOHERTY GEORGE A (US)
HALE JEFFREY J (US)
LYNCH CHRISTOPHER (US)
MILLS SANDER G (US)
NEWAY WILLIAM EDWARD III (US)
TOTH LESLIE (US)

Application Number:

PCT/US2004/014837

Publication Date:

May 19, 2005

Filing Date:

May 12, 2004

Export Citation:

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Assignee:

MERCK & CO INC (US)
COLANDREA VINCENT J (US)
DOHERTY GEORGE A (US)
HALE JEFFREY J (US)
LYNCH CHRISTOPHER (US)
MILLS SANDER G (US)
NEWAY WILLIAM EDWARD III (US)
TOTH LESLIE (US)

International Classes:

C07D413/04; A61K; (IPC1-7): C07D413/04

Foreign References:

US3647809A

1972-03-07

Other References: