5-AROMATIC ALKYNYL SUBSTITUTED BENZAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF

Title:

5-AROMATIC ALKYNYL SUBSTITUTED BENZAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/165658

Kind Code:

A1

Abstract:

The present invention relates to the fields of pharmaceutical chemistry and drug therapy, and particularly relates to a compound of formula I, and a preparation method and use thereof as a negative allosteric modulator of a metabotropic glutamate receptor (mGluR) subtype 5.

Inventors:

LIU HONG (CN)
ZHOU YU (CN)
ZHANG DONG (CN)
LI JIAN (CN)
JIANG HUALIANG (CN)
CHEN KAIXIAN (CN)

Application Number:

PCT/CN2016/079496

Publication Date:

October 20, 2016

Filing Date:

April 15, 2016

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA CAS (CN)

International Classes:

C07D213/56; C07D213/75; C07D213/82; C07D239/26; C07D277/30; C07D401/12; C07D417/06; C07D417/10; C07D417/12; C07D417/14

Domestic Patent References:

WO2001053274A1	2001-07-26
WO2006044823A2	2006-04-27
WO2010124047A1	2010-10-28
WO1999002497A2	1999-01-21
WO2006029980A1	2006-03-23
WO2005094822A1	2005-10-13
WO2009143404A1	2009-11-26

Foreign References:

CN103596568A	2014-02-19
JPH10195063A	1998-07-28

Other References: