ALLELE-SPECIFIC siRNA-MEDIATED GENE SILENCING

Title:

ALLELE-SPECIFIC siRNA-MEDIATED GENE SILENCING

Document Type and Number:

WIPO Patent Application WO2004013280

Kind Code:

A3

Abstract:

The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.

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Inventors:

DAVIDSON BEVERLY L (US)
GONZALEZ-ALEGRE PEDRO (US)
MILLER VICTOR (US)
PAULSON HENRY (US)
HARPER SCOTT (US)

Application Number:

PCT/US2003/016887

Publication Date:

December 29, 2005

Filing Date:

May 26, 2003

Export Citation:

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Assignee:

UNIV IOWA RES FOUND (US)
DAVIDSON BEVERLY L (US)
GONZALEZ-ALEGRE PEDRO (US)
MILLER VICTOR (US)
PAULSON HENRY (US)
HARPER SCOTT (US)

International Classes:

C07H21/02; C12N5/22; C12N15/113; C12N15/861; A61K38/00; A61K48/00; (IPC1-7): C12Q1/68; C12P19/34; C12N15/63; C12N15/88; C07H21/02; C07H21/04; A01N43/04

Foreign References:

US6387616B1	2002-05-14
US5902880A	1999-05-11
US20020086356A1	2002-07-04

Other References:

FIRE A. ET AL: "Potent and specific genetic interference by double-stranded RNA in C. elegans.", NATURE., vol. 391, 19 February 1998 (1998-02-19), pages 806 - 811, XP002938525

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