ACYLSULFAMIDE INHIBITORS OF FACTOR VIIA

Title:

ACYLSULFAMIDE INHIBITORS OF FACTOR VIIA

Document Type and Number:

WIPO Patent Application WO2004113278

Kind Code:

A3

Abstract:

Compounds having the general formula (I) are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties. These compounds may be used in methods of preventing and/or treating clotting disorders.

Inventors:

GAZZARD LEWIS J (GB)
RAWSON THOMAS E (US)

Application Number:

PCT/US2004/015915

Publication Date:

February 17, 2005

Filing Date:

May 19, 2004

Export Citation:

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Assignee:

GENENTECH INC (US)
GAZZARD LEWIS J (GB)
RAWSON THOMAS E (US)

International Classes:

A61P7/02; C07C307/06; C07C311/51; C07D307/79; C07D307/80; C07D307/81; C07D307/82; C07D307/86; (IPC1-7): C07C307/06; C07D307/79; A61K31/325; A61K31/343; A61P7/02

Domestic Patent References:

WO2000041531A2

2000-07-20

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