Title:
ADMINISTRATION AND MONITORING OF NITRIC OXIDE IN EX
VIVO FLUIDS
Document Type and Number:
WIPO Patent Application WO/2015/084698
Kind Code:
A3
Abstract:
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits or perfusion fluids used for preserving ex vivo organs prior to transplanting in a recipient. The systems and methods described herein provide for administering nitric oxide to the fluid, monitoring nitric oxide or a nitric oxide marker in the fluid, and adjusting the nitric oxide administration.
Inventors:
POTENZIANO JIM (US)
HANSELL DOUGLAS R (US)
GRIEBEL JEFF (US)
COSTA EDDIE (US)
COOPER LISA (US)
HANSELL DOUGLAS R (US)
GRIEBEL JEFF (US)
COSTA EDDIE (US)
COOPER LISA (US)
Application Number:
PCT/US2014/067856
Publication Date:
November 05, 2015
Filing Date:
December 01, 2014
Export Citation:
Assignee:
INO THERAPEUTICS LLC (US)
International Classes:
A01N1/02
Domestic Patent References:
| WO2013070712A1 | 2013-05-16 |
Other References:
Y. ISHIBE ET AL: "Role of inhaled nitric oxide in ischaemia-reperfusion injury in the perfused rabbit lung", BRITISH JOURNAL OF ANAESTHESIA, vol. 83, no. 3, 1 September 1999 (1999-09-01), pages 430 - 435, XP055173147, ISSN: 0007-0912, DOI: 10.1093/bja/83.3.430
J. DOUGLAS AITCHISON ET AL: "Nitric oxide during perfusion improves posttransplantation function of non??? heart-beating donor lungs12", TRANSPLANTATION, vol. 75, no. 12, 1 June 2003 (2003-06-01), pages 1960 - 1964, XP055173154, ISSN: 0041-1337, DOI: 10.1097/01.TP.0000067528.58552.34
SHINYA MURAKAMI ET AL: "Effects of Various Timings and Concentrations of Inhaled Nitric Oxide in Lung Ischemia-Reperfusion", AM J RESPIR CRIT CARE MED, vol. 156, 1 January 1997 (1997-01-01), pages 454 - 458, XP055173061
GERD HERMLE ET AL: "Ventilation-Perfusion Mismatch after Lung Ischemia-Reperfusion", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 160, no. 4, 1 October 1999 (1999-10-01), pages 1179 - 1187, XP055174193, ISSN: 1073-449X, DOI: 10.1164/ajrccm.160.4.9808034
J. DOUGLAS AITCHISON ET AL: "Nitric oxide during perfusion improves posttransplantation function of non??? heart-beating donor lungs12", TRANSPLANTATION, vol. 75, no. 12, 1 June 2003 (2003-06-01), pages 1960 - 1964, XP055173154, ISSN: 0041-1337, DOI: 10.1097/01.TP.0000067528.58552.34
SHINYA MURAKAMI ET AL: "Effects of Various Timings and Concentrations of Inhaled Nitric Oxide in Lung Ischemia-Reperfusion", AM J RESPIR CRIT CARE MED, vol. 156, 1 January 1997 (1997-01-01), pages 454 - 458, XP055173061
GERD HERMLE ET AL: "Ventilation-Perfusion Mismatch after Lung Ischemia-Reperfusion", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 160, no. 4, 1 October 1999 (1999-10-01), pages 1179 - 1187, XP055174193, ISSN: 1073-449X, DOI: 10.1164/ajrccm.160.4.9808034
Attorney, Agent or Firm:
ALEGRIA, Rory P. (33 Wood Avenue SouthSecond Floor, Suite 21, Iselin New Jersey, US)
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