AGENT FOR EXTERNAL APPLICATION TO THE SKIN

WIPO Patent Application WO/2007/114380

A1

The object is to provide an agent for external application, which can rapidly suppress itching on the skin, particularly on the hypersensitive skin. Disclosed is an agent for external application to the skin, which is characterized in that a lower alcohol (e.g., ethanol) is not used or, if any, is used in a small amount in combination with capsaicin and crotamiton. The agent comprises capsaicin, crotamiton, and a lower alcohol in an amount of not less than 0% by weight and less than 5% by weight. Since the agent contains capsaicin and crotamiton but does not contain a lower alcohol or, if any, contains a lower alcohol in only an extremely small amount, the agent can develop an itching-suppressing effect immediately after the application of the agent to the skin.

WO/2008/039863	COMPOSITION COMPRISING A MELANOCORTIN RECEPTOR (MCR) MODULATING AGENT ALONE OR IN COMBINATION WITH A SECOND NEUROGENIC AGENT FOR TREATING NERVOUS SYSTEM DISORDERS
WO/1998/017268	METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST
WO/1993/020046	INDAN-1,3-DIONE AND INDAN-1,2,3-TRIONE DERIVATIVES, PROCESSES FOR PREPARATION OF SAME AND THEIR USE AS THERAPEUTIC AGENTS

NOZAKI MANABU (JP)
SAWAMURA SHIGEKI (JP)

PCT/JP2007/057245

October 11, 2007

March 30, 2007

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KOBAYASHI PHARMA (JP)
NOZAKI MANABU (JP)
SAWAMURA SHIGEKI (JP)

A61K31/165; A61K8/34; A61K8/42; A61K9/06; A61K31/167; A61K47/10; A61K47/24; A61K47/44; A61P17/00; A61P17/04; A61P43/00; A61Q19/00

WO2001010435A1

2001-02-15

JPH1045569A	1998-02-17
JP2001213772A	2001-08-07
JP2000143507A	2000-05-23
JP2003095985A	2003-04-03
JP2004026721A	2004-01-29

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