Title:
AGENT FOR INCREASING TRANSLATION INITIATION FACTOR OR TRANSLATION ELONGATION FACTOR, AND USE THEREOF FOR MEDICAL PURPOSES
Document Type and Number:
WIPO Patent Application WO/2012/014993
Kind Code:
A1
Abstract:
[Problem]
The purpose of the present invention is to provide a pharmaceutical preparation for preventing and/or treating various diseases, which comprises a compound capable of increasing a translation initiation factor or a transcription elongation factor or a pharmaceutically acceptable salt thereof as an active ingredient.
[Solution]
The present inventors made extensive studies for the purpose of solving the problem, and it is found for the first time that the increase in a translation initiation factor (e.g., eIF4A1) or a translation elongation factor (e.g., eEF1A1) is involved in the NGF-induced neurite elongation potentiating activity of minocycline or cilostazol, and the invention has been accomplished.
Inventors:
HASHIMOTO KENJI (JP)
ISHIMA TAMAKI (JP)
ISHIMA TAMAKI (JP)
Application Number:
PCT/JP2011/067315
Publication Date:
February 02, 2012
Filing Date:
July 28, 2011
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
HASHIMOTO KENJI (JP)
ISHIMA TAMAKI (JP)
HASHIMOTO KENJI (JP)
ISHIMA TAMAKI (JP)
International Classes:
A61K31/65; A61K31/4709; A61P3/00; A61P5/00; A61P7/00; A61P9/00; A61P11/00; A61P25/18; A61P31/04; A61P35/00; A61P37/00; A61P43/00; C07D401/12
Domestic Patent References:
| WO2006082390A1 | 2006-08-10 |
Foreign References:
| JP2008273953A | 2008-11-13 |
Other References:
TOMOKO NISHIMURA ET AL.: "PC12 Saibo o Mochiita Shinkei Eiyo Inshi (NGF) Yuhatsu no Shinkei Tokki Shincho Sokushin ni Okeru Shinkei Yakurigakuteki Kenkyu", CHIBA MEDICAL JOURNAL, vol. 83, no. 5, 2007, pages 204 - 205
KANG, Y.M. ET AL.: "Thermosensitive polymer-based hydrogel mixed with the anti-inflammatory agent minocycline induces axonal regeneration in hemisected spinal cord", MACROMOLECULAR RESEARCH, vol. 18, no. 4, April 2010 (2010-04-01), pages 399 - 403
DATABASE BIOSIS AMEENUDDIN, S. ET AL.: "The role of minocycline in promoting axonal regeneration in biodegradable polymer implants seeded with Schwann cells in the rat spinal cord", accession no. STN Database accession no. PREV200400199572
KEILHOFF, G. ET AL.: "Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration", EXP NEUROL, vol. 212, no. 1, 2008, pages 189 - 200, XP022714975, DOI: doi:10.1016/j.expneurol.2008.03.028
FUJITA, Y. ET AL.: "Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline", PROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRY, vol. 32, no. 2, 2008, pages 336 - 339, XP022452757, DOI: doi:10.1016/j.pnpbp.2007.08.031
ZHANG, L. ET AL.: "Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine", NEUROPSYCHOPHARMACOLOGY, vol. 32, no. 9, 2007, pages 2004 - 2010
DATABASE PUBMED [online] U.S. NATIONAL LIBRARY OF MEDICINE(NLM); LEVKOVITZ, Y. ET AL.: "A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia", retrieved from http://www.ncbi. nlm.nih.gov/pubmed/19895780 accession no. NCBI Database accession no. 19895780
LEVINE, J. ET AL.: "Possible antidepressant effect of minocycline", AM J PSYCHIATRY, vol. 153, no. 4, 1996, pages 582, XP009099813
SONG, Y. ET AL.: "Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation", BRAIN RES, vol. 1085, no. 1, 2006, pages 57 - 67, XP025065295, DOI: doi:10.1016/j.brainres.2006.02.042
CHOI Y. ET AL.: "Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models", NEUROPSYCHOPHARMACOLOGY, vol. 32, no. LL, 2007, pages 2393 - 2404
HASHIMOTO, K. ET AL.: "A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation factor eIF4AI, art. e15430", PLOS ONE, vol. 5, no. 11, November 2010 (2010-11-01), pages 1 - 9
KENJI HASHIMOTO: "Development of new therapeutic drugs based on the pathophysiology of schizophrenia", JAPANESE JOURNAL OF BIOLOGICAL PSYCHIATRY, vol. 22, May 2011 (2011-05-01), pages 80
YAMAMOTO, Y. ET AL.: "et al, Effects of cilostazol, an antiplatelet agent, on axonal regeneration following nerve injury in diabetic rats", EUR J PHARMACOL, vol. 352, no. 2-3, 1998, pages 171 - 178
BABA, H. ET AL.: "Seven cases of late-life depression treated with cilostazol-augmented therapy", J CLIN PSYCHOPHARMACOL, vol. 27, no. 6, 2007, pages 727 - 728
HASHIMOTO, K. ET AL.: "Neurite outgrowth mediated by translation elongation factor eEFlAl: a target for antiplatelet agent cilostazol, art. e17431", PLOS ONE, vol. 6, no. 3, March 2011 (2011-03-01), pages 1 - 8
KANG, Y.M. ET AL.: "Thermosensitive polymer-based hydrogel mixed with the anti-inflammatory agent minocycline induces axonal regeneration in hemisected spinal cord", MACROMOLECULAR RESEARCH, vol. 18, no. 4, April 2010 (2010-04-01), pages 399 - 403
DATABASE BIOSIS AMEENUDDIN, S. ET AL.: "The role of minocycline in promoting axonal regeneration in biodegradable polymer implants seeded with Schwann cells in the rat spinal cord", accession no. STN Database accession no. PREV200400199572
KEILHOFF, G. ET AL.: "Minocycline protects Schwann cells from ischemia-like injury and promotes axonal outgrowth in bioartificial nerve grafts lacking Wallerian degeneration", EXP NEUROL, vol. 212, no. 1, 2008, pages 189 - 200, XP022714975, DOI: doi:10.1016/j.expneurol.2008.03.028
FUJITA, Y. ET AL.: "Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antibiotic drug minocycline", PROG NEUROPSYCHOPHARMACOL BIOL PSYCHIATRY, vol. 32, no. 2, 2008, pages 336 - 339, XP022452757, DOI: doi:10.1016/j.pnpbp.2007.08.031
ZHANG, L. ET AL.: "Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine", NEUROPSYCHOPHARMACOLOGY, vol. 32, no. 9, 2007, pages 2004 - 2010
DATABASE PUBMED [online] U.S. NATIONAL LIBRARY OF MEDICINE(NLM); LEVKOVITZ, Y. ET AL.: "A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia", retrieved from http://www.ncbi. nlm.nih.gov/pubmed/19895780 accession no. NCBI Database accession no. 19895780
LEVINE, J. ET AL.: "Possible antidepressant effect of minocycline", AM J PSYCHIATRY, vol. 153, no. 4, 1996, pages 582, XP009099813
SONG, Y. ET AL.: "Minocycline protects PC12 cells against NMDA-induced injury via inhibiting 5-lipoxygenase activation", BRAIN RES, vol. 1085, no. 1, 2006, pages 57 - 67, XP025065295, DOI: doi:10.1016/j.brainres.2006.02.042
CHOI Y. ET AL.: "Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models", NEUROPSYCHOPHARMACOLOGY, vol. 32, no. LL, 2007, pages 2393 - 2404
HASHIMOTO, K. ET AL.: "A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation factor eIF4AI, art. e15430", PLOS ONE, vol. 5, no. 11, November 2010 (2010-11-01), pages 1 - 9
KENJI HASHIMOTO: "Development of new therapeutic drugs based on the pathophysiology of schizophrenia", JAPANESE JOURNAL OF BIOLOGICAL PSYCHIATRY, vol. 22, May 2011 (2011-05-01), pages 80
YAMAMOTO, Y. ET AL.: "et al, Effects of cilostazol, an antiplatelet agent, on axonal regeneration following nerve injury in diabetic rats", EUR J PHARMACOL, vol. 352, no. 2-3, 1998, pages 171 - 178
BABA, H. ET AL.: "Seven cases of late-life depression treated with cilostazol-augmented therapy", J CLIN PSYCHOPHARMACOL, vol. 27, no. 6, 2007, pages 727 - 728
HASHIMOTO, K. ET AL.: "Neurite outgrowth mediated by translation elongation factor eEFlAl: a target for antiplatelet agent cilostazol, art. e17431", PLOS ONE, vol. 6, no. 3, March 2011 (2011-03-01), pages 1 - 8
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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