Title:
AGENT FOR REDUCING ADVERSE SIDE EFFECTS OF KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/081154
Kind Code:
A1
Abstract:
The present invention relates to: an agent for reducing adverse side effects, which contains at least one branched amino acid selected from isoleucine, leucine and valine or a salt of the branched amino acid as an active ingredient and can reduce the adverse side effects of a kinase inhibitor; and an anti-cancer medicinal agent which comprises at least one branched amino acid selected from isoleucine, leucine and valine or a salt of the branched amino acid and a kinase inhibitor.
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Inventors:
YAMAMOTO NAOKI (JP)
SAKAIDA ISAO (JP)
SAKAIDA ISAO (JP)
Application Number:
PCT/JP2012/081213
Publication Date:
June 06, 2013
Filing Date:
November 30, 2012
Export Citation:
Assignee:
AJINOMOTO KK (JP)
UNIV YAMAGUCHI (JP)
UNIV YAMAGUCHI (JP)
International Classes:
A61K31/198; A61K31/44; A61K45/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2004058243A1 | 2004-07-15 | |||
| WO2004058243A1 | 2004-07-15 | |||
| WO2007013677A1 | 2007-02-01 |
Foreign References:
| JP2006528196A | 2006-12-14 | |||
| JP2011512395A | 2011-04-21 | |||
| JP2006503105A | 2006-01-26 |
Other References:
AKIHARU WATANABE, SOSETSU: "Kansaibo Gan no Eiyo Yobo", PHARMA MEDICA, vol. 17, no. 3, 1999, pages 177 - 189, XP008173808
ELEY,H.L. ET AL.: "Effect of branched-chain amino acids on muscle atrophy in cancer cachexia", BIOCHEM. J., vol. 407, 2007, pages 113 - 120, XP008119488
MASAFUMI IKEDA: "Tokushu Gan Bunshi Hyoteki Chiryo no Genjo to Tenbo ''5. Rinsho de Bunshi Hyotekiyaku o Shiyo suru Sai no Point to Kadai 3) Kansaibo Gan''", PROG. MED., vol. 31, no. 11, 2011, pages 2607 - 2613, XP008173471
MINORI ODANAKA ET AL.: "Session 3-A Kansaibo Gan Kanja ni Okeru Sorafenib no Teashi Hifu Hanno no Risk Inshi", LIVER CANCER J., vol. 3, no. 2, 2011, pages 144 - 145, XP008173809
SHIN'YA SUZUKI ET AL.: "Note ''Evaluation of Improvement of Adherence Following Pharmacist Intervention for Hand/Foot Skin Reactions Induced by Sorafenib''", IRYO YAKUGAKU, vol. 37, no. 5, 2011, pages 317 - 321, XP008173462
NEMOTO ET AL.: "Investigation of the Utility of Branched-Chain Amino Acids (BCAA) in a Mouse Model for Non-Alcoholic Steatohepatitis (NASH", THE JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 105, 2008, pages A832
See also references of EP 2786750A4
ELEY,H.L. ET AL.: "Effect of branched-chain amino acids on muscle atrophy in cancer cachexia", BIOCHEM. J., vol. 407, 2007, pages 113 - 120, XP008119488
MASAFUMI IKEDA: "Tokushu Gan Bunshi Hyoteki Chiryo no Genjo to Tenbo ''5. Rinsho de Bunshi Hyotekiyaku o Shiyo suru Sai no Point to Kadai 3) Kansaibo Gan''", PROG. MED., vol. 31, no. 11, 2011, pages 2607 - 2613, XP008173471
MINORI ODANAKA ET AL.: "Session 3-A Kansaibo Gan Kanja ni Okeru Sorafenib no Teashi Hifu Hanno no Risk Inshi", LIVER CANCER J., vol. 3, no. 2, 2011, pages 144 - 145, XP008173809
SHIN'YA SUZUKI ET AL.: "Note ''Evaluation of Improvement of Adherence Following Pharmacist Intervention for Hand/Foot Skin Reactions Induced by Sorafenib''", IRYO YAKUGAKU, vol. 37, no. 5, 2011, pages 317 - 321, XP008173462
NEMOTO ET AL.: "Investigation of the Utility of Branched-Chain Amino Acids (BCAA) in a Mouse Model for Non-Alcoholic Steatohepatitis (NASH", THE JAPANESE JOURNAL OF GASTROENTEROLOGY, vol. 105, 2008, pages A832
See also references of EP 2786750A4
Attorney, Agent or Firm:
SHIGA Masatake et al. (JP)
Masatake Shiga (JP)
Masatake Shiga (JP)
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